Use of over-the-counter malaria medicines in children and adults in three districts in Kenya: implications for private medicine retailer interventions
© Abuya et al; licensee BioMed Central Ltd. 2007
Received: 15 February 2007
Accepted: 10 May 2007
Published: 10 May 2007
Global malaria control strategies highlight the need to increase early uptake of effective antimalarials for childhood fevers in endemic settings, based on a presumptive diagnosis of malaria in this age group. Many control programmes identify private medicine sellers as important targets to promote effective early treatment, based on reported widespread inadequate childhood fever treatment practices involving the retail sector. Data on adult use of over-the-counter (OTC) medicines is limited. This study aimed to assess childhood and adult patterns of OTC medicine use to inform national medicine retailer programmes in Kenya and other similar settings.
Large-scale cluster randomized surveys of treatment seeking practices and malaria parasite prevalence were conducted for recent fevers in children under five years and recent acute illnesses in adults in three districts in Kenya with differing malaria endemicity.
A total of 12, 445 households were visited and data collected on recent illnesses in 11, 505 children and 19, 914 adults. OTC medicines were the most popular first response to fever in children with fever (47.0%; 95% CI 45.5, 48.5) and adults with acute illnesses (56.8%; 95% CI 55.2, 58.3). 36.9% (95% CI 34.7, 39.2) adults and 22.7% (95% CI 20.9, 24.6) children using OTC medicines purchased antimalarials, with similar proportions in low and high endemicity districts. 1.9% (95% CI 0.8, 4.2) adults and 12.1% (95% CI 16.3,34.2) children used multidose antimalarials appropriately. Although the majority of children and adults sought no further treatment, self-referral to a health facility within 72 hours of illness onset was the commonest pattern amongst those seeking further help.
In these surveys, OTC medicines were popular first treatments for fever in children or acute illnesses in adults. The proportions using OTC antimalarials were similar in areas of high and low malaria endemicity. In all districts, adults were more likely to self-treat with OTC antimalarial medicines than febrile children were to receive them, and less likely to use them in recommended ways. Government health centres were the most common second resort for treatment and were often used within 72 hours. In view of these practices, more research is needed to assess the impact on the popularity of private medicine sellers of strengthened public sector policies on access to malaria treatment and insecticide-treated bed nets. Improved targeting of OTC antimalarials to high risk groups, better communication strategies regarding adult as well as children's dosages, and facilitating more rapid referral to trained health workers where needed are important challenges to private medicine seller programmes.
Malaria continues to be a major cause of death and disability  and contributes to economic weaknesses in poor countries  despite increased international support for, and coordination of, research and control efforts [3, 4]. Insecticide-treated bed nets (ITNs) and intermittent presumptive treatment of malaria in pregnant women and infants have been shown to be successful control measures, and research on malaria vaccines holds promise for the future [4–7]. However, the availability of prompt effective treatment of clinical malaria will remain a fundamental control mechanism either alone or alongside additional measures, where these can be effectively implemented . There are macroeconomic and political challenges in ensuring that effective antimalarial medicines are available through the public sector at country level [8–10]. In Kenya, for example, implementation of antimalarial drug policy changes in 2005 occurred more than 32 months after the initial decision, as a result of complex financing and procurement systems and prolonged negotiations with the pharmaceutical industry . Socio-economic and geographic barriers to treatment through government clinics and hospitals has led to a proliferation of untrained private medicine sellers in many settings . In recognition of the latter phenomenon and the problems associated with practices in this sector, international and national malaria control strategies have identified private medicine sellers as an important target to promote appropriate home treatment [13, 14].
Since 2001, the Kenya National Malaria Strategy (KNMS) has supported the implementation of programmes targeting private sellers of OTC medicines and their clients within district malaria control activities . Thirty-three districts have obtained support to implement educational programmes for medicine sellers and communities on the use of antimalarial medicines in the home from the Global Fund to fight AIDS, Tuberculosis and Malaria (GFATM). In April 2004, Kenya changed the first-line recommended antimalarial drug policy from Sulphadoxine/Sulphalene-pyrimethamine medicines (SP) to the artemesinin-based combination therapies (ACT), with a phased introduction through the formal government and mission sectors, to be followed by the private formal sector. The policy proposed ultimate inclusion of private medicine sellers, depending on early experiences with the change .
In this paper, we present data from household surveys of treatment seeking behaviour for recent childhood fevers and adult illnesses, and on malaria prevalence in well children under five years, in rural areas of three districts in Kenya. The data were collected during surveys conducted collaboratively by the Kenyan Medical Research Institute (KEMRI) Wellcome Trust Research Programme and the Division of Malaria Control (DOMC) in the Kenyan Ministry of Health (MOH) in 2002 and 2003 in districts with varying malaria transmission. The surveys aimed to inform the planning and evaluation of district-led training programmes for private medicine retailers and communities on malaria and its treatment. Data from the malaria parasite prevalence surveys are presented in this paper as markers for transmission pressure in the study sites, and for comparison with treatment-seeking behavior patterns. The findings are discussed with particular emphasis on adult OTC antimalarial use as an emerging challenge to programmes addressing this sector.
Study sites and population
Population and number of health facilities in study divisions
Number of government health centres
Number of government dispensaries
Number of private pharmacies
Study design and method
This was a descriptive study based on cluster randomized cross sectional household surveys conducted during the peak malaria transmission season in each district. The methods used were surveys of reported treatment seeking behaviour for recent illness episodes in young children and adults, and malaria parasite prevalence surveys in a sub sample of well children using rapid diagnostic tests.
In each study division, a list of National Census enumeration areas was used to construct a sampling frame and units for the household survey. Since some enumeration areas were much larger than others, to avoid weighting the chances of selection by population size, those with greater than 110 households were subdivided into smaller units prior to randomisation. In each district, a total of 4,000 households were identified in randomly selected enumeration areas (or subdivisions) of approximately 100 households. The sample size calculation was derived for planned future evaluations of the retailer training programmes, with a primary outcome of the proportion of childhood fevers treated with OTC antimalarials that included an adequate amount of the MOH recommended treatment. Since the future evaluations planned to include both intra and inter-district comparisons, sample sizes for the current household survey were calculated around comparisons of these proportions within districts, providing standard errors of 1.6% and 2.2% around estimations of 10% and 20% respectively (coefficient of variation 0.2) .
Locally recruited and trained field workers collected detailed information on treatment seeking behaviour for children under five years of age with a recent fever and for adults present in the household at the time of interview with a recent acute illness, using a structured questionnaire. Recent episodes were defined as those occurring within a two-week period of the interview. In this survey, two target age groups were identified; children under five who present the greatest vulnerability to severe disease, and individuals over the age of fourteen years, as an adult group likely to make an autonomous decision on treatment seeking. To counteract the potential for reporting bias, a pre-tested questionnaire developed and validated from previous studies was used , and field workers used drug charts containing samples of commonly used OTC medicines to aid recall and validate reports, and remaining packages or tablets were reviewed where possible. Data were checked for inaccuracies and inconsistencies daily before double entry and verification using FOXPRO version 6 (Microsoft Corp, Redmond, WA, USA). Adjustment was made for clustering at EA level using Svy data commands in STATA version 8 (Stata Corp, College Station, Texas, USA). Proportions for key outcomes are presented with 95% confidence intervals. Chi-square tests of association were used to compare proportions across the districts and analysis of variance (ANOVA) models were used to compare means. Since one of the most common OTC antimalarial medicines in use, amodiaquine (AQ), has a three-day regime of administration, episodes where treatment was started within three days of the interview were excluded.
Malaria parasite prevalence surveys
Randomly identified sub-samples of 971, 963 and 980 children from the household survey in Busia, Kwale and Makueni districts, respectively, were invited to participate in a cross sectional survey of malaria parasite and anaemia prevalence. The prevalence of anaemia was assessed during the baseline as a marker for programme impact in the future, and data on haemoglobin concentrations are not presented in this paper. The sample size was based on a conservative estimate of 50% prevalence for moderately severe anaemia , with a confidence interval of 44% – 56%. Participants were screened at temporary local centers using rapid diagnostic tests for malaria (Uni-Gold ™ Trinity Biotech, Ireland). Children with parasitaemia and a history of fever and those with anaemia were provided with treatment in accordance with a treatment protocol approved by the national Scientific Coordinating Committee and the District Medical Officer of Health.
The Kenya National Scientific Steering and Ethical Committees and World Health Organization Ethics Review Committee granted approval for the study. The aim and purpose of all components of the study was discussed and agreed with local leaders. Verbal informed consent was sought for the household survey and information sheets including contact details were left in each home visited. Signed informed consent was obtained from parents or guardians for the malaria parasite prevalence survey. Reports on the findings of the surveys were sent to District Health Management Teams.
Number of households visited, prevalence of illnesses, use of OTC antimalarials and malaria parasite prevalence (%: 95% CI)
P values *
Children under 5 years
(41.7: 39.5, 43.9)
(43.3: 41.5, 45.2)
(30.8: 28.7, 33.0)
(29.0: 28.1, 29.8)
Fevers first treated with OTC medicines†
(37.6: 35.1, 40.1)
(50.7: 48.3, 53.1)
(52.7: 49.8, 55.5)
(47.0: 45.5, 48.5)
OTC users taking an AM‡
(45.7: 41.3, 50.1)
(16.3: 13.9, 18.9)
(13.3: 9.5, 17.9)
(22.7: 20.9, 24.6)
OTC SP users taking adequate dose§
(48.3: 37.9, 58.8)
(48.6: 32.5, 64.9)
(40.4: 19.0, 66.3)
(46.4: 39.5, 53.4)
OTC AQ users taking adequate dose
(14.2: 8.7, 22.2)
(9.1: 4.0, 19.5)
(10.7: 3.4, 28.9)
(12.1: 16.3, 34.2)
Rapid malaria test positive
(82.8: 79.0, 86.1)
(71.1: 64.4, 76.9)
(3.2: 2.1, 4.8)
(52.6: 50.8, 54.4)
(16.6: 14.4, 19.0)
(26.7: 24.9, 28.6)
(18.2: 17.1, 19.4)
(20.6: 20.0, 21.1)
First treated with OTC medicines
(46.0: 42.8, 49.1)
(61.1: 58.8, 63.3)
(59.5: 56.7, 62.2)
(56.8: 55.2, 58.3)
OTC users taking an AM
(26.9: 21.3, 33.5)
(53.3: 48.6, 57.9)
(36.9: 34.7, 39.2)
OTC SP users taking adequate dose
(78.3: 68.4, 85.8)
(79.4: 68.3, 87.3)
(87.7: 81.5, 92.0)
(83.8: 78.7, 86.6)
OTC AQ users taking adequate dose
(4.4: 1.1, 16.6)
(2.4: 0.9, 6.0)
(1.9: 0.8, 4.2)
National guidelines on dosage by age for SP medicines. [1 tab = 500 mg sulphadoxine, 25 mg pyrimethamine; 5 ml = 250 mg sulphadoxine, 12.5 mg pyrimethamine]
Total no spoons syrup
Days given over
Total no tabs
Total in mg*
tsp (5 ml)
tbs (10 ml)
1/2 – 3/4
250 – 375
1 – 1 1/2
1/2 – 3/4
12 – 59 months
1 – 1 1/4
500 – 625
2 – 2 1/2
1 – 1 1/4
1 1/2 – 1 3/4
National guidelines on dosage by age for AQ medicines. [1 tab = 200 mg AQ base; 5 ml = 50 mg AQ base]
Total no spoons syrup
Days given over
Total no tabs
Total in mg
tsp (5 ml)
tbs (10 ml)
< 6 months
3/4 – 1
150 – 200
3 – 4 1/2
1 1/2 – 2
6 – 11 months
1 1/4 – 1 3/4
250 – 350
5 – 7 1/2
2 1/2 – 3 1/2
12 – 47 months
2 – 2 1/4
400 – 450
7 1/2 – 9 1/2
4 – 5
48 – 71 months
2 1/2 – 3 1/2
500 – 700
10 – 14 1/2
5 – 7
15 – 16 years
16 + years
6 1/2–7 1/2 -
Actions following first use of OTC medicines (%: 95% CI)
No further action after OTC
2nd action is use of clinic
Visits clinic within 48 h*
No further action after OTC
2nd action is use of clinic
Visits clinic within 48 h
Given the high global burden of young childhood disease and deaths attributed to malaria [1, 2], early effective treatment of childhood fevers has become a main focus within global and national malaria control strategies [3, 13, 14]. Such strategies highlight the role of private medicine retailers to promote early effective home treatment of childhood malaria in endemic settings . More recently, the introduction of ACTs as first line treatment for malaria in many countries in sub Saharan Africa has led to debate on the role of community-based mechanisms for delivery of malaria treatments [20–23]. Understanding patterns of OTC medicine use is important to assess the opportunities and challenges of programmes for private medicine retailers, but there is limited detailed data on adult OTC antimalarial use in the literature [23–26]. This study reports on patterns of OTC medicines use from large-scale surveys including child and adult populations across three districts in Kenya with varying malaria endemicity.
In interpreting these results, it is important to consider limitations of the study methods. The data on treatment seeking behaviour were collected from reports concerning recent illness episodes. While standard practices were used to ensure that these were as accurate as possible (careful training and supervision of interviewers, internal validity checks in questionnaires, use of locally constructed drug charts with packaging and logo visuals to aid recognition, and inspection of left-over tablets), this type of data is always open to recall and reporting biases. In the household survey, for pragmatic reasons, histories were elicited for all children within a household who met inclusion criteria for age, including siblings. Theoretically, this may lead to clustering of data within households for which no allowance has been made in the analysis. Confidence intervals could therefore be wider than those stated here, although these are generally small given the size of these surveys. There is some evidence that intra-household clustering would have a negligible effect; a study in rural Tanzania found no difference in the outcome of an analysis of treatment seeking behaviour for all young children and for only one randomly selected child within that household . Finally, these data were collected from surveys conducted in 2002 and 2003, at a time when the recommended first line antimalarial medicine in Kenya was SP. Practices of drug use may have changed over time, and care should be taken in extrapolating these results to understand use of other antimalarial medicines. However, the pattern of poor adherence with multidose medicines is not a new or isolated phenomenon [28, 29] and many factors underlying medicine use for acute illnesses (cost, complexity of regimen and rate of response) are likely to be generalisable.
The data presented here concur with earlier descriptions of the popularity of private medicine sellers as an early treatment option for childhood fevers, and the inappropriate ways in which OTC antimalarial medicines are generally used in young children [17, 23, 30–33]. The study further illustrates that adults with a recent acute illness were more likely to use an antimalarial medicine than were young children to receive them for a febrile illness, even in hypoendemic districts. These findings reinforce the need to intervene in a sector that is chaotic but potentially offers an opportunity to improve early fever treatment practices in children. They also point to shortcomings in applying current global home malaria management strategies that focus primarily on young children to private retail sector interventions. While the under five age group experiences the greatest burden of malaria disease in endemic settings, adult use of OTC antimalarials may represent a greater challenge to strategies to optimise their use .
There is limited information on adult use of OTC antimalarial medicines. Several studies have addressed the frequency of OTC antimalarial use in adult populations in specific settings, but there is less information on the way that these medicines are used, or from large-scale surveys in areas of varying malaria endemicity. A study of OTC antimalarial use in a highland area of low seasonal malaria transmission in Kenya described a similar excess of adult over paediatric use (24% of adult and 14% of child OTC users purchased an antimalarial) . High use of OTC antimalarials has been described for older school children in Kenya , as have similarities between adult and child use of OTC antipyretic and antimalarial medicines in a qualitative study in Ghana .
Adult over-use of antimalarials is an important phenomenon because of the potential for wastage of resources where adults have a lower risk of malaria than children. The extent of over-use is highlighted by the popularity of these medicines even in areas with low and seasonal malaria transmission. Adult over-use affects estimations of the volume of malaria medicines used in the private retail sector and therefore has an economic implication for governments and households, particularly in anticipation of, or following, the introduction of ACTs . There may be an impact of under dosing on the development of drug resistance. Although the relationship between these is not straightforward, resistance is likely to be selected for where partially effective treatments result in recrudescence of infection . If under dosing contributes to increased resistance of malaria parasites to antimalarial medicines, the widespread existence of such practices amongst adults as well as children can only increase this effect.
For both adults and children, there are clear differences in adherence to SP and AQ medicines, with adherence to SP being much higher than AQ. This finding is likely to be a result of the different regimes for administration, with SP medicines being given in a single dose in contrast to the 3-day AQ regimen. There is evidence that other multiple dose medicines, such as chloroquine, have commonly been used as single doses in the past, including in Kenya . Adherence to multidose ACTs may present a similar problem, particularly given the speed of response of symptoms, such as fever, to this group of medicines. Although high adherence to ACTs has been documented in the formal sector [37, 38], under-dosing is often a cost-saving strategy [32, 39] and is, therefore, particularly likely to affect private retail sector treatments where the costs are directly related to the quantity of medicine obtained. This incentive to cut down on full courses of medicines may plausibly be greater for adults than for young children in keeping with the larger amounts of medication that they require. In this survey, adult AQ adherence is considerably worse than that reported for children.
A further pattern of interest emerging from the study concerns movement between private medicine sellers and trained health workers. Amongst the minority (14.4%), who sought further treatment after using OTC medicines, most carers (approximately 84%) chose to visit a trained health worker. Self referral to such a facility did not generally occur within 24 hours of onset of illness, as recommended by the Roll Back Malaria initiative , but the majority did seek further assistance by 72 hours. Kemble et al studied this pattern of self referral in an urban population in Kampala, finding a much higher proportion (42%) of child OTC users were subsequently taken to a formal provider, although with similar timing . In an epidemic area in Uganda, health facilities were reported as the commonest first line treatment for both adults and children with suspected malaria . More research on these patterns, and the factors underlying self-referral behaviour would help to elucidate opportunities for optimising these practices.
Programmes for private medicine retailers in malaria control have been based on pragmatic principles, and these still obtain. The challenges of working with informal private providers have been well articulated at the policy level, including the size of the sector in many countries, lack of regulatory mechanisms and capacity, lack of organizational structures, multiplicity of brands, inadequate quality of OTC medicines, difficulties in diagnosing malaria clinically and commercial interests of retailers [5, 12, 20, 41, 42]. However, unit dose pre-packaging interventions have already been shown to improve adherence with multidose medicines, and may prove effective for antimalarial medicines in the private retail sector (10, 41). The opportunities provided by this sector have also proved compelling, including sustainability, cost and coverage [31, 36, 43, 44], particularly given the shortcomings reported in the public sector, reviewed recently by Zurovac and Rowe . Mills et al illustrate this pragmatism writing that "...training and investment in formal sector providers (public and private) and restructuring of the market so as to strengthen the purchasing and regulation functions of government, may displace the informal sector, but this is likely to be a very long term process" . The data presented in this paper show that the group of mothers who visit a health facility as a second option is a minority, but that this self-referral occurs relatively quickly, even in rural settings. Kemble suggests that faster movement to a health centre may be achievable with the provision of adequate, acceptable and affordable services and a better public understanding of the need for rapid treatment of childhood fevers . This data also indicate that interventions directed at increasing usage of health facilities may be feasible and play an important part in improving early effective malaria treatment. With recent increased investment in malaria control activities, further research is needed to establish the extent to which the introduction of free, effective antimalarial treatment in government health facilities, and the wider availability of free or affordable ITNs can influence the balance of choice for users between trained public and untrained commercial providers in the future, taking account of socio-economic and geographic differences. Where OTC antimalarial use remains a popular option, greater targeting of antimalarial medicines to high risk populations, and away from the current predominantly adult market, will be an important challenge for private medicine retailer programmes in the future [12, 23, 24].
The findings of this survey across three districts of differing malaria endemicity in Kenya confirm the common use of OTC medicines for fever in children and acute illnesses in adults, as well as the widespread inappropriate use of these medicines. They point to the frequent use of OTC antimalarial medicines in adults, irrespective of disease transmission rates, and the high risk that this will be accompanied by under dosing. A minority of OTC users subsequently seek further treatment through the formal sector, but many of these self-referrals occur within 72 hours of onset of illness even in rural situations. More research is needed to assess the impact on the popularity of private medicine sellers of free malaria treatment in public health facilities for children under five years and increased community coverage with treated bed nets. Improved targeting of OTC antimalarial medicines to high risk groups, better communication strategies on adult as well as children's dosages, and facilitating appropriate referral to trained health workers are important challenges to private medicine seller programmes.
We acknowledge the great support and contributions of the District Health Management Teams, administrative leaders, field workers, community members and medicine retailers in Busia, Kwale and Makueni districts. Richard Rimba and Francis Kombe provided invaluable support to the surveys. Bob Snow, Catherine Goodman and Abdinasir Amin read and commented on earlier versions of the manuscript. Funding support for the surveys was provided by the Kenya Medical Research Institute (KEMRI), the Wellcome Trust and the World Health Organization Kenya Country Office. This paper is published with the permission of the Director of KEMRI.
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