Volume 8 Supplement 1

Coartem®: reviewing the impact on the malaria landscape

Reviews

Edited by Marcel Hommel

Publication of this supplement has been sponsored by Novartis Pharma AG.

  1. Review

    Coartem®: the journey to the clinic

    Artemisinin, from which the artemether component of Coartem®(artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chin...

    Zulfiqarali G Premji

    Malaria Journal 2009 8(Suppl 1):S3

    Published on: 12 October 2009

  2. Review

    Understanding the pharmacokinetics of Coartem®

    Artemether and lumefantrine (AL), the active constituents of Coartem® exhibit complementary pharmacokinetic profiles. Artemether is absorbed quickly; peak concentrations of artemether and its main active metaboli...

    Abdoulaye Djimdé and Gilbert Lefèvre

    Malaria Journal 2009 8(Suppl 1):S4

    Published on: 12 October 2009

  3. Review

    The clinical efficacy of artemether/lumefantrine (Coartem®)

    Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT preq...

    Michael Makanga and Srivicha Krudsood

    Malaria Journal 2009 8(Suppl 1):S5

    Published on: 12 October 2009

  4. Review

    Safety profile of Coartem®: the evidence base

    This article reviews the comprehensive data on the safety and tolerability from over 6,300 patients who have taken artemether/lumefantrine (Coartem®) as part of Novartis-sponsored or independently-sponsored clini...

    Catherine Falade and Christine Manyando

    Malaria Journal 2009 8(Suppl 1):S6

    Published on: 12 October 2009

  5. Review

    Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia

    Malaria is one of the most significant causes of morbidity and mortality worldwide. Every year, nearly one million deaths result from malaria infection. Malaria can be controlled in endemic countries by using ...

    Karen I Barnes, Pascalina Chanda and Gebre Ab Barnabas

    Malaria Journal 2009 8(Suppl 1):S8

    Published on: 12 October 2009

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