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  1. Research

    Effects of community-level bed net coverage on malaria morbidity in Lilongwe, Malawi

    The protective effect of insecticide-treated bed nets against individual-level malaria transmission is well known, however community-level effects are less understood. Protective effects from community-level b...

    Veronica Escamilla, Alisa Alker, Leonard Dandalo, Jonathan J. Juliano, William C. Miller, Portia Kamthuza, Tapiwa Tembo, Gerald Tegha, Francis Martinson, Michael Emch and Irving F. Hoffman

    Malaria Journal 2017 16:142

    Published on: 7 April 2017

  2. Meeting report

    Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

    The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacifi...

    Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P. Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J. Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M. Aktaruzzaman, Nayeem Sohel, Rinzin Namgay…

    Malaria Journal 2017 16:141

    Published on: 5 April 2017

  3. Research

    Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

    A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated wit...

    Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco and Hervé Bogreau

    Malaria Journal 2017 16:140

    Published on: 5 April 2017

  4. Research

    Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

    Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must b...

    Myo Thiha Zaw, Myo Thant, Tin Maung Hlaing, Naing Zin Aung, Min Thu, Kanit Phumchuea, Kanokwan Phusri, Teerawat Saeseu, Ritthideach Yorsaeng, Wang Nguitragool, Ingrid Felger, Jaranit Kaewkungwal, Liwang Cui and Jetsumon Sattabongkot

    Malaria Journal 2017 16:138

    Published on: 4 April 2017

  5. Methodology

    A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions

    Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission-blocking drugs and vaccines ...

    Ellie Sherrard-Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough and Michael Betancourt

    Malaria Journal 2017 16:137

    Published on: 4 April 2017

  6. Research

    Prevalence and genetic variants of G6PD deficiency among two Malagasy populations living in Plasmodium vivax-endemic areas

    The prevalence and variants of G6PD deficiency in the Plasmodium vivax-endemic zones of Madagascar remain unknown. The admixed African-Austronesian origins of the Malagasy population make it probable that a heter...

    Rosalind E. Howes, Ernest R. Chan, Tovonahary Angelo Rakotomanga, Seth Schulte, John Gibson, Melinda Zikursh, Thierry Franchard, Brune Ramiranirina, Arsène Ratsimbasoa and Peter A. Zimmerman

    Malaria Journal 2017 16:139

    Published on: 4 April 2017

  7. Opinion

    World Malaria Report: time to acknowledge Plasmodium knowlesi malaria

    The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the...

    Bridget E. Barber, Giri S. Rajahram, Matthew J. Grigg, Timothy William and Nicholas M. Anstey

    Malaria Journal 2017 16:135

    Published on: 31 March 2017

  8. Research

    Perceptions of malaria control and prevention in an era of climate change: a cross-sectional survey among CDC staff in China

    Though there was the significant decrease in the incidence of malaria in central and southwest China during the 1980s and 1990s, there has been a re-emergence of malaria since 2000.

    Michael Xiaoliang Tong, Alana Hansen, Scott Hanson-Easey, Scott Cameron, Jianjun Xiang, Qiyong Liu, Xiaobo Liu, Yehuan Sun, Philip Weinstein, Gil-Soo Han, Craig Williams and Peng Bi

    Malaria Journal 2017 16:136

    Published on: 31 March 2017

  9. Research

    Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria

    Control of malaria increasingly involves administration of 8-aminoquinolines, with accompanying risk of haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Few data on the preva...

    Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W. F. Kingston, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Abul Faiz, Nicholas M. Anstey, Nicholas P. J. Day, Md. Amir Hossain, Mallika Imwong, Arjen M. Dondorp and Charles J. Woodrow

    Malaria Journal 2017 16:134

    Published on: 29 March 2017

  10. Research

    Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180

    Although a number of Plasmodium vivax proteins have been identified, few have been investigated as potential vaccine candidates. This study characterized the Plasmodium vivax merozoite surface antigen 180 (PvMSA1...

    Fauzi Muh, Jin-Hee Han, Myat Htut Nyunt, Seong-Kyun Lee, Hye-Yoon Jeon, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Md Atique Ahmed, Sunghun Na, Eizo Takashima, Takafumi Tsuboi and Eun-Taek Han

    Malaria Journal 2017 16:133

    Published on: 28 March 2017

  11. Research

    Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon

    Chloroquine had been used extensively during the last five decades in Cameroon. Its decreasing clinical effectiveness, supported by high proportions of clinical isolates carrying the mutant pfcrt haplotype (CVIET...

    Nicaise Tuikue Ndam, Leonardo K. Basco, Vincent Foumane Ngane, Ahidjo Ayouba, Eitel Mpoudi Ngolle, Philippe Deloron, Martine Peeters and Rachida Tahar

    Malaria Journal 2017 16:130

    Published on: 27 March 2017

  12. Research

    A novel in vitro model reveals distinctive modulatory roles of Plasmodium falciparum and Plasmodium vivax on naïve cell-mediated immunity

    To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and...

    Setthakit Chitsanoor, Sangdao Somsri, Panyu Panburana, Mathirut Mungthin, Ratawan Ubalee, Maliwan Emyeam, Somchai Jongwutiwes, Jetsumon Sattabongkot and Rachanee Udomsangpetch

    Malaria Journal 2017 16:131

    Published on: 27 March 2017

  13. Research

    Predictors of the use of interventions to prevent malaria in pregnancy in Cameroon

    Malaria in pregnancy is common in sub-Saharan Africa where it contributes to perinatal morbidity and mortality. Use of insecticide-treated bed nets and intermittent preventive therapy with sulfadoxine–pyrimeth...

    Jodie Dionne-Odom, Andrew O. Westfall, Tobias O. Apinjoh, Judith Anchang-Kimbi, Eric A. Achidi and Alan T. N. Tita

    Malaria Journal 2017 16:132

    Published on: 27 March 2017

  14. Research article

    Analytical sensitivity of current best-in-class malaria rapid diagnostic tests

    Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, for the confirmation of suspected cases before the administration of anti-ma...

    Alfons Jimenez, Roxanne R. Rees-Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding

    Malaria Journal 2017 16:128

    Published on: 24 March 2017

  15. Case report

    Diagnostic challenges and case management of the first imported case of Plasmodium knowlesi in Sri Lanka

    Sri Lanka has achieved ‘malaria-free’ status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges en...

    A. Dewanee Ranaweera, Manjula N. Danansuriya, Kusumawathie Pahalagedera, W. M. Kumudunayana T. de A. W. Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C. Hapuarachchi, Hema D. B. Herath and Deepika Fernando

    Malaria Journal 2017 16:126

    Published on: 21 March 2017

  16. Research

    Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

    Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcr...

    Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya, Bryan Greenhouse and Philip J. Rosenthal

    Malaria Journal 2017 16:125

    Published on: 21 March 2017

  17. Research

    False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

    Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a dele...

    Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad

    Malaria Journal 2017 16:123

    Published on: 20 March 2017

  18. Research

    Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

    Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To o...

    Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D. Legason, Martin D. Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J. Reynolds, Patrick Kerchan, Moses M. Joloba, Andrew W. Bergen, Kishor Bhatia, Ambrose O. Talisuna, Robert J. Biggar…

    Malaria Journal 2017 16:124

    Published on: 20 March 2017

  19. Research

    Clinical and molecular surveillance of drug resistant vivax malaria in Myanmar (2009–2016)

    One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being ...

    Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han and Eun-Taek Han

    Malaria Journal 2017 16:117

    Published on: 16 March 2017

  20. Research

    Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

    In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance of Plasm...

    Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta and Bruno Pradines

    Malaria Journal 2017 16:118

    Published on: 16 March 2017

  21. Research

    Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar

    Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of mala...

    Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim and Byoung-Kuk Na

    Malaria Journal 2017 16:119

    Published on: 16 March 2017

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