Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Table 1 In vitro sensitivity of isolate NGATV01 and strain K1 to standard antimalarial drugs with standard deviations (nmol/L).

Drug	NGATV01	K1	Resistance Cut-off^*
	Mean IC ₅₀ ± SD	Mean IC ₅₀ ± SD
Chloroquine	9.54 ± 1.18	133.29 ± 30.12	100
Mefloquine	24.14 ± 5.20	8.55 ± 0.29	20
Pyrimethamine	16012.80 ± 2643.55	8082.84 ± 1202.69	100
Atovaquone	1888.15 ± 106.65	2.41 ± 1.01	20
Proguanil	4205.50 ± 716.99	10239.94 ± 843.51	not determined
Dihydroartemisinin	2.39 ± 0.07	1.26 ± 0.46	not determined

Drug assay was performed at 1 % parasitaemia and 1 % haematocrit. Experiment was repeated twice in duplicate.^* Cut-off points for resistance as previously reported [16, 17, 6]

ISSN: 1475-2875