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Table 2 Total distribution of resistance-associated mutations and wild type among imported isolates of P. falciparum in Europe

From: Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe

Resistance to Gene locus Mutation (%) Wild type (%) Total
Chloroquine Pfcrt 76 204 (68.2%) 95 (31.8%) 299
  Pfmdr 86 85 (42.3%) 116 (57.7%) 201
Group I antifolates DHFR 51 135 (44.3%) 170 (55.7%) 305
  DHFR 108 170 (58.4%) 121 (41.6%) 291
  DHFR 59 156 (55.1%) 127 (44.9%) 283
Group II antifolates DHPS 436 79 (33.3%) 158 (66.7%) 237
  DHPS 437 92 (40.4%) 136 (59.6%) 228
  DHPS 540 12 (5.3%) 216 (94.7%) 228
  DHPS 581 6 (2.3%) 255 (97.7%) 261
  1. Group I antifolates: e.g. pyrimethamine. Group II antifolates: sulfonamides DHFR = dihydrofolate reductase DHPS = dihydropteroate synthetase