Table 2 Total distribution of resistance-associated mutations and wild type among imported isolates of P. falciparum in Europe
Resistance to | Gene locus | Mutation (%) | Wild type (%) | Total |
|---|---|---|---|---|
Chloroquine | Pfcrt 76 | 204 (68.2%) | 95 (31.8%) | 299 |
Pfmdr 86 | 85 (42.3%) | 116 (57.7%) | 201 | |
Group I antifolates | DHFR 51 | 135 (44.3%) | 170 (55.7%) | 305 |
DHFR 108 | 170 (58.4%) | 121 (41.6%) | 291 | |
DHFR 59 | 156 (55.1%) | 127 (44.9%) | 283 | |
Group II antifolates | DHPS 436 | 79 (33.3%) | 158 (66.7%) | 237 |
DHPS 437 | 92 (40.4%) | 136 (59.6%) | 228 | |
DHPS 540 | 12 (5.3%) | 216 (94.7%) | 228 | |
DHPS 581 | 6 (2.3%) | 255 (97.7%) | 261 |