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Figure 4 | Malaria Journal

Figure 4

From: Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

Figure 4

PfPP1 dose response to inhibitors. Inhibition assays for recombinant PfPP1 were performed using 32P-phosphorylase a as substrate essentially as described [14]. The inhibitors and the symbols are: tautomycin (square), inhibitor-2 (diamond), OA (triangle), and I-1 (circle). The half-closed and fully closed diamonds represent I-2 against the double mutant (E52A/E54A) and triple mutant (D164A/E165A/K166A) enzymes, respectively. Activities are expressed as percentage of the inhibitor-free reaction. As shown, the X-axis represents negative logarithm of molar concentration of the inhibitors.

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