Figure 4
Parasite-specific IgG and IgM antibody responses of ICR mice after P. yoelii infection. Mice were infected with 107 P. yoelii 17XL and treated with maslinic acid or left untreated. Sera from cured mice of the primary infection were collected at day 30. Sera from not cured mice correspond to day 5 after first infection (black bars). The surviving mice were reinfected at day 40 and sera was collected at day 10 after the reinfection (white bars). Results are presented as mean+SD immunoglobulin concentrations from three measurements, each containing pooled sera obtained from 6 mice. Statistical significant differences (P< 0.05) between infected MA-treated and non-treated groups are indicated by an asterisk.