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Table 2 Sensitivity, specificity & ROC* for saliva derived seroprevalence to P. falciparum merozoite surface antigens

From: Human saliva as a source of anti-malarial antibodies to examine population exposure to Plasmodium falciparum

  Sensitivity (95% CI) Specificity (95% CI) ROC (95% CI)
AMA-1    
Tanzania Oracol 76.7 (54.9-90.6) 100 (87.7-100) 0.88 (0.8-0.96)
Tanzania Orasure 64 (42.5-82) 92.9 (76.5-99.1) 0.78 (0.68-0.89)
The Gambia 68 (56-78.8) 91.2(85-95.6) 0.80(0.74-0.86)
MSP-1 19    
Oracol 46.7 (21.3-73.4) 97.4 (86.2-99.9) 0.72 (0.58-0.85)
Orasure 66.7 (38.4-88.2) 90.0(75.2-97.1) 0.78 (0.64-0.91)
The Gambia 53 (40.1-66.5) 94.2(89-87.5) 0.74(0.67-0.81)
  1. * ROC = receiver operating characteristic curve; the average of sensitivity and specificity
  2. Fingerprick derived plasma antibody prevalence was the gold standard for sensitivity and specificity analysis.