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Table 1 List of important differentially expressed probes after administration of AQ in murine Liver.

From: A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

Spot labels

Fold Change

Gene Name/Description

GO : Biological function

11544

2.27

TAP binding protein

antigen processing

20523

2.73

RAB39B, member RAS oncogene family

GTP binding

18680

2.49

Neogenin

ATP binding

11260

2.18

ATPase, Ca++ transporting, plasma membrane 1

ATP binding

12910

2.20

Dihydropyrimidinase-like 5

axon guidance

18325

3.18

Calcium channel, voltage-dependent, L type, alpha 1D subunit

calcium channel activity

9921

3.51

Ankyrin repeat domain 6

DNA binding

18064

6.11

GATA binding protein 2

DNA binding

20032

2.51

Parathyroid hormone receptor 1

G-protein coupled receptor activity

12886

3.62

Transmembrane protein with EGF-like and two follistatin-like domains 1

growth factor activity

21365

3.33

Solute carrier family 38, member 1

L-glutamine transport

492

6.38

DNA segment, Chr 5, Wayne State University 178, expressed

phospholipid biosynthesis

22462

-4.53

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

ATP-dependent helicase activity

10941

-2.32

Calcium channel, voltage-dependent, L type, alpha 1C subunit

calcium channel activity

2989

-2.69

Nucleoporin 153

DNA binding

22225

-4.12

Suppressor of variegation 4-20 homolog 1 (Drosophila)

histone lysine N-methyltransferase activity

15707

-2.09

Lipoma HMGIC fusion partner-like 2

metabolism

9653

-2.55

GCN5 general control of amino acid synthesis-like 2 (yeast)

N-acetyltransferase activity

7818

-2.15

Nuclear receptor subfamily 3, group C, member 2

transcription factor activity

  1. Fold change (FC) >2(Up-regulated) and FC<-2 (Down-regulated) and P < 0.01.