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Table 3 List of Important differentially expressed probes after administration of AQ+SP in murine Liver.

From: A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

Spot labels

Fold

Change

Gene Name/Description

GO: Biological Function

3557

2.03

Cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1

Calcium ion binding

1410

3.02

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

Integral to plasma membrane

16564

2.50

Kelch-like 2, Mayven (Drosophila)

Actin binding

5639

2.51

Integrin beta 8

Cell adhesion

10049

2.49

Suppression of tumorigenicity 14 (colon carcinoma)

Cell migration

21956

2.25

Mortality factor 4 like 1

Cell proliferation

14809

2.61

Zinc finger, SWIM domain containing 4

Cellular component

21155

2.42

Metal response element binding transcription factor 1

DNA binding

21758

3.61

Regulatory factor X, 3 (influences HLA class II expression)

DNA binding

1649

5.71

Polymerase (RNA) III (DNA directed) polypeptide F

DNA binding

20006

3.53

Cytochrome b5 type B

Electron transport

12949

2.47

GTP binding protein (gene overexpressed in skeletal muscle)

GTP binding

492

2.47

DNA segment, Chr 5, Wayne State University 178, expressed

Integral to membrane

11468

3.82

DNA segment, Chr 18, ERATO Doi 653, expressed

Integral to membrane

9206

2.18

Dystrobrevin binding protein 1

Muscle development

12725

3.03

Dolichyl-di-phosphooligosaccharide-protein glycotransferase

N-linked glycosylation via asparagine

14957

3.64

Adenosine deaminase, RNA-specific, B2

RNA binding

15208

2.70

Solute carrier family 25 (mitochondrial carrier, glutamate), member 22

Transporter activity

22601

3.18

Ubiquitin-conjugating enzyme E2D 2

Ubiquitin-dependent protein catabolism

10183

-2.83

Lysophospholipase 3

Acyltransferase activity

6999

-3.22

Mitogen activated protein kinase 14

ATP binding

22383

-2.63

Transforming growth factor, beta receptor I

ATP binding

2877

-2.03

Procollagen, type VI, alpha 3

Cell adhesion

18522

-3.11

Microfibrillar-associated protein 4

Cell adhesion

874

-3.24

BTB and CNC homology 2

DNA binding

11690

-8.17

CXXC finger 1 (PHD domain)

DNA binding

13862

-2.05

GLI-Kruppel family member GLI3

DNA binding

19141

-2.44

Protein disulfide isomerase associated 6

DNA binding

17585

-2.07

AT rich interactive domain 5B (Mrf1 like)

DNA binding

18686

-3.25

Cytochrome b5 type B

Electron transport

16362

-3.08

Proteasome (prosome, macropain) subunit, beta type 2

Endopeptidase activity

20020

-4.67

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

Glycerophospholipid metabolism

13958

-2.83

RAS related protein 1b

GTP binding

11531

-3.27

Zinc metallopeptidase, STE24 homolog (S. cerevisiae)

Hydrolase activity

13203

-2.64

SH2-B PH domain containing signaling mediator 1

Intracellular signaling cascade

19040

-2.26

Malate dehydrogenase 2, NAD (mitochondrial)

Malate dehydrogenase activity

5575

-2.06

Ring finger protein (C3HC4 type) 19

Protein ubiquitination

6605

-3.30

Cleavage and polyadenylation specific factor 4

RNA binding

  1. Fold change (FC) >2(Up regulated) and FC<-2 (Down regulated) and P < 0.01.