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Table 3 List of Important differentially expressed probes after administration of AQ+SP in murine Liver.

From: A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

Spot labels Fold
Change
Gene Name/Description GO: Biological Function
3557 2.03 Cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 Calcium ion binding
1410 3.02 Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 Integral to plasma membrane
16564 2.50 Kelch-like 2, Mayven (Drosophila) Actin binding
5639 2.51 Integrin beta 8 Cell adhesion
10049 2.49 Suppression of tumorigenicity 14 (colon carcinoma) Cell migration
21956 2.25 Mortality factor 4 like 1 Cell proliferation
14809 2.61 Zinc finger, SWIM domain containing 4 Cellular component
21155 2.42 Metal response element binding transcription factor 1 DNA binding
21758 3.61 Regulatory factor X, 3 (influences HLA class II expression) DNA binding
1649 5.71 Polymerase (RNA) III (DNA directed) polypeptide F DNA binding
20006 3.53 Cytochrome b5 type B Electron transport
12949 2.47 GTP binding protein (gene overexpressed in skeletal muscle) GTP binding
492 2.47 DNA segment, Chr 5, Wayne State University 178, expressed Integral to membrane
11468 3.82 DNA segment, Chr 18, ERATO Doi 653, expressed Integral to membrane
9206 2.18 Dystrobrevin binding protein 1 Muscle development
12725 3.03 Dolichyl-di-phosphooligosaccharide-protein glycotransferase N-linked glycosylation via asparagine
14957 3.64 Adenosine deaminase, RNA-specific, B2 RNA binding
15208 2.70 Solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Transporter activity
22601 3.18 Ubiquitin-conjugating enzyme E2D 2 Ubiquitin-dependent protein catabolism
10183 -2.83 Lysophospholipase 3 Acyltransferase activity
6999 -3.22 Mitogen activated protein kinase 14 ATP binding
22383 -2.63 Transforming growth factor, beta receptor I ATP binding
2877 -2.03 Procollagen, type VI, alpha 3 Cell adhesion
18522 -3.11 Microfibrillar-associated protein 4 Cell adhesion
874 -3.24 BTB and CNC homology 2 DNA binding
11690 -8.17 CXXC finger 1 (PHD domain) DNA binding
13862 -2.05 GLI-Kruppel family member GLI3 DNA binding
19141 -2.44 Protein disulfide isomerase associated 6 DNA binding
17585 -2.07 AT rich interactive domain 5B (Mrf1 like) DNA binding
18686 -3.25 Cytochrome b5 type B Electron transport
16362 -3.08 Proteasome (prosome, macropain) subunit, beta type 2 Endopeptidase activity
20020 -4.67 Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide Glycerophospholipid metabolism
13958 -2.83 RAS related protein 1b GTP binding
11531 -3.27 Zinc metallopeptidase, STE24 homolog (S. cerevisiae) Hydrolase activity
13203 -2.64 SH2-B PH domain containing signaling mediator 1 Intracellular signaling cascade
19040 -2.26 Malate dehydrogenase 2, NAD (mitochondrial) Malate dehydrogenase activity
5575 -2.06 Ring finger protein (C3HC4 type) 19 Protein ubiquitination
6605 -3.30 Cleavage and polyadenylation specific factor 4 RNA binding
  1. Fold change (FC) >2(Up regulated) and FC<-2 (Down regulated) and P < 0.01.