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Table 4 List of genes with their description and expression results by Q-PCR and microarray following treatment with AQ and SP in murine liver.

From: A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

Gene Symbol

Gene Name/Description

Q-PCR fold change

Microarray Result Up regulated(â–²)/Down regulated (â–¼)

ADRA1B

Adrenergic receptor, alpha 1b

-6

â–²

CYP1A2

Cytochrome P450, family 1, subfamily a, polypeptide 2

-6

â–¼

CYP2E1

Cytochrome P450, family 2, subfamily e, polypeptide 1

-5

â–¼

SC4MOL

Sterol-C4-methyl oxidase-like

-4

â–¼

H2DM

Histocompatibility 2, class II,

1.2

â–²

RAC

RAS-related C3 botulinum

-1.8

â–¼

MCM4

Minichromosome maintenance deficient 4 homolog

5

â–²

VKORC

Vitamin K epoxide reductase complex,

-1.5

â–¼

SC5D

Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog

7

â–²

ADH1

Alcohol dehydrogenase 1 (class I)

4.8

â–²

GADD45

Growth arrest and DNA-damage-inducible 45 gamma

3.2

â–²

UGT2B1

UDP glucuronosyltransferase 2 family, polypeptide B1

5

â–²

MCM5

Minichromosome maintenance deficient 5 homolog

2.5

â–²

GCGR

Glucagon receptor

8

â–²

  1. Note the direction similarity among Q-PCR and microarray findings for gene expression results.