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Table 2 Parameter estimates, standard error, and bootstrap confidence intervals for final model

From: Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

Parameter Estimate %RSE Bootstrap mean (95% CI)
K12 (h-1) 4.28 23.6 4.43 (2.73-7.16)
D2 (h) 4.04 19.5 3.99 (2.37-6.27)
ALAG1 (h) 0.627 10.9 0.630 (0.494-0.771)
F1 0.864 1.56 0.867 (0.839-0.887)
CL/F (L/h) 895 5.9 904 (788-1045)
V2/F (L) 195 16.4 201 (139-285)
CLM/F (L/h) 64.0 6.53 64.2 (55.1-75.2)
V3/F (L) 91.4 6.15 92.1 (78.5-109)
PREG on CLM/F 0.423 30.3 0.427 (0.197-0.723)
IIV - Variances (%CV)    
IIV - K12 1.84 (136) 25.3 1.76 (0.986-2.77)
IIV - D2 1.33 (115) 22.9 1.33 (0.64-2.15)
IIV - ALAG 0.573 (75.7) 20.8 0.581 (0.333-0.91)
IIV - V2/F 0.604 (77.7) 30.1 0.568 (0.253-0.942)
IIV - CLM/F 0.0802 (28.3) 24.9 0.0711 (0.031-0.113)
IIV - V3/F 0.0790 (28.1) 34.7 0.00661 (0.00591-0.139)
RV - Variances    
AS 0.696 11.6 0.721 (0.515-0.971)
DHA 0.174 9.94 0.174 (0.129-0.226)
  1. RSE: Relative standard error; K12: rate of first-order absorption process for AS; D2: duration of zero-order absorption process for AS; ALAG1: lag time for first-order absorption process; F1: fraction of dose absorbed by the first-order process; CL/F: apparent clearance of AS; V2/F: apparent volume of distribution of AS; CLM/F: apparent clearance of DHA; V3/F: apparent volume of distribution of DHA; PREG on CLM/F: factor of proportional increase in CLM/F associated with pregnancy; IIV: Interindividual variability.