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Table 2 Parameter estimates, standard error, and bootstrap confidence intervals for final model

From: Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

Parameter

Estimate

%RSE

Bootstrap mean (95% CI)

K12 (h-1)

4.28

23.6

4.43 (2.73-7.16)

D2 (h)

4.04

19.5

3.99 (2.37-6.27)

ALAG1 (h)

0.627

10.9

0.630 (0.494-0.771)

F1

0.864

1.56

0.867 (0.839-0.887)

CL/F (L/h)

895

5.9

904 (788-1045)

V2/F (L)

195

16.4

201 (139-285)

CLM/F (L/h)

64.0

6.53

64.2 (55.1-75.2)

V3/F (L)

91.4

6.15

92.1 (78.5-109)

PREG on CLM/F

0.423

30.3

0.427 (0.197-0.723)

IIV - Variances (%CV)

   

IIV - K12

1.84 (136)

25.3

1.76 (0.986-2.77)

IIV - D2

1.33 (115)

22.9

1.33 (0.64-2.15)

IIV - ALAG

0.573 (75.7)

20.8

0.581 (0.333-0.91)

IIV - V2/F

0.604 (77.7)

30.1

0.568 (0.253-0.942)

IIV - CLM/F

0.0802 (28.3)

24.9

0.0711 (0.031-0.113)

IIV - V3/F

0.0790 (28.1)

34.7

0.00661 (0.00591-0.139)

RV - Variances

   

AS

0.696

11.6

0.721 (0.515-0.971)

DHA

0.174

9.94

0.174 (0.129-0.226)

  1. RSE: Relative standard error; K12: rate of first-order absorption process for AS; D2: duration of zero-order absorption process for AS; ALAG1: lag time for first-order absorption process; F1: fraction of dose absorbed by the first-order process; CL/F: apparent clearance of AS; V2/F: apparent volume of distribution of AS; CLM/F: apparent clearance of DHA; V3/F: apparent volume of distribution of DHA; PREG on CLM/F: factor of proportional increase in CLM/F associated with pregnancy; IIV: Interindividual variability.
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Malaria Journal

ISSN: 1475-2875

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