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Figure 2 | Malaria Journal

Figure 2

From: Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model

Figure 2

Replacement strategy of mutant Pfdhfr-ts into Pbdhfr-ts by double cross-over homologous recombination. (A) endogenous Pbdhfr-ts gene locus in PbGFP wild-type parasite, (B) linearized plasmid pY005 containing mutant PfdhfrS108N, (C) PfdhfrS108N-ts gene locus in transgenic PbPf S108N parasite. Positions of primers used for PCR amplification are indicated by arrows. The expected size of PCR products are described.

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Malaria Journal

ISSN: 1475-2875

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