Skip to main content

Table 1 Baseline Characteristics and results of the SP efficacy study

From: High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

Number of patients

29

Age, mean (SD), months

34.8 (16.6)

Sex ratio (male/female)

1.9 (19/10)

Weight, mean (SD), kg

13.0 (2.5)

Axillary temperature at admission, mean (SD), °C

37.1 (0.95)

Parasitaemia at admission, median (quartiles)

18,718 (2,800-33,300)

Day 28 PCR adjusted cure in PP analysis, n (%) Day 28 unadjusted cure in PP analysis, n (%)

12/26 (46) 10/26 (38.5)

Early treatment failures, n (%)

1 (4)

Late parasitological failures, n (%)

13 (50)

Parasite clearance time, mean (95%CI), hours

61 (45-76)

Fever clearance time, mean (95%CI), hours

22 (14-30)

Gametocyte carrier rate at admission, n (%)

2 (6)

Gametocytes carrier rate during follow-up, n (%)

22 (85)

  1. SD: Standard Deviation, PCR: Polymerase Chain Reaction, CI: Confidence Interval, n: number of patients.