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Table 4 Prevalence of dhfr gene mutations at enrolment and at day of failure in children included in the in vivo study

From: High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

DHFR

Pre-treatment

N = 29

Codon

51

59

108

164

Sensitive

N

C

S

I

 

1 (3%)

2 (7%)

0

28 (97%)

Mutant

I

R

N

L

 

23 (79%)

26 (90%)

26 (90%)

0

No PCR product

5

1

3

1

Post-treatment

N = 26

Codon

51

59

108

164

Sensitive

N

C

S

I

 

0

0

0

12 (46%)

Mutant

I

R

N

L

 

8 (31%)

12 (46%)

10 (38%)

0

No PCR product

18

14

16

14

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Malaria Journal

ISSN: 1475-2875

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