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Table 1 Analysis of polymorphism and selection in Pf38 sequences (85-892 bp) in different P. falciparu m populations

From: Population genetic analysis of the Plasmodium falciparum 6-cys protein Pf38 in Papua New Guinea reveals domain-specific balancing selection

  Codon based Z tests (p-value) McDonald-Kreitman Allele frequency based tests
  n Sa dN dS h Hd Π (×103) K (×103) HKAr dN = dS dN > dS dN < dS SYN NONSYN   Tajima's D Fu & Li F
              Fixed Poly Fixed Poly p-value   
Full (85-892bp)                    
   Mugil 36 10 9 0 11 0.88 3.24 18.97 0.17 0.014* 0.007* 1 4 0 9 9 0.115 0.331 0.303
   Wosera 23 8 7 0 9 0.86 2.81 18.24 0.15 0.067 0.035* 1 4 0 9 7 0.248 0.151 -0.397
   Gambia 88 13 11 1 36 0.95 4.04 19.09 0.21 0.015* 0.007* 1 4 1 9 11 0.321 0.432 1.057
Domain I (85-466bp)                    
   Mugil 36 6 6 0 6 0.82 5.74 18.33 0.31 0.023* 0.012* 1 4 0 1 6 0.015* 1.407 1.475#
   Wosera 23 7 7 0 8 0.85 5.71 17.53 0.33 0.026* 0.012* 1 4 0 1 7 0.010* 0.475 0.108
   Gambia 88 9 8 1 23 0.90 6.69 17.85 0.37 0.021* 0.009* 1 4 1 1 8 0.0229* 1.106 0.908
Domain II (467-892bp)                    
   Mugil 36 4 3 0 5 0.35 0.99 19.55 0.05 0.101 0.052 1 0 0 8 3 n/a -1.3773 -1.336
   Wosera 23 1 n/a n/a 2 0.09 0.20 18.88 0.01 0.295 1 0.151 0 0 8 0 n/a -1.161 -1.640
   Gambia 88 4 3 0 4 0.60 1.63 20.20 0.08 0.32 0.154 1 0 0 8 3 n/a -0.247 0.668
  1. *significant (p < 0.05) #aproaching significance (p < 0.10) n/a = not applicable
  2. n = number of sequences, S = number of polymorphic sites, dN = nonsynonymous polymorphisms, dS = synonymous polymorphisms, h = haplotypes, Hd = Haplotype diversity, Π = nucleotide diversity, K = interspecific divergence, HKAr = HK, A ratio (Π/K)
  3. aThere is a polymorphism within an incomplete codon at the 3' end of the sequence, preventing determination of NS or Syn, which explains the lower number of dN+dS than S