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Figure 1 | Malaria Journal

Figure 1

From: Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis

Figure 1

Plasma concentrations of antiretroviral drugs (raltegravir, maraviroc, etravirine and saquinavir) evaluated as Area Under Curve (AUC) before starting atovaquone/proguanil (pre) and at day 20 of prophylaxis (post). The D AUC0-12h represents the difference in AUC0-12h (during prophylaxis AUC minus pre-prophylaxis AUC). An HPLC-UV method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new non- nucleoside reverse transcriptase inhibitor etravirine, protease inhibitor saquinavir and CCR-5 inhibitor maraviroc was used [11, 12].

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