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Table 2 Pharmacotechnical characteristics of ASAQ alcoholic/aqueous granulation tablet formulations with or without binder*

From: The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership

Batch n° 11128G 11213(1) 11129 11128P 11124 11130
Tablet dosage AS/AQ (mg/mg) 100/270 100/270 100/270 25/67,5 25/67,5 25/67,5
Granulation Aqueous + PVP* Alcoholic + PVP* Alcoholic without PVP* Aqueous + PVP* Alcoholic + PVP* Alcoholic without PVP*
Mean tablet weight (mg) 494 480 476 129 123 120
Hardness (N) 73 65 69 72 60 59
Disintegration time (min) 4 < 1 < 1 5 < 3 < 3
Friability (%) 1.25 ND 2.6 0.7 ND 1.04
Drugs released after 45 min of dissolution test (AQ%/AS%) 92/76 94/83 98/91 100/86 ND 100/106
  1. Key: ND = not determined; binder = PVP K30 10% solution