Table 2 Pharmacotechnical characteristics of ASAQ alcoholic/aqueous granulation tablet formulations with or without binder*

Tablet dosage AS/AQ (mg/mg)

100/270

100/270

100/270

25/67,5

25/67,5

25/67,5

Granulation

Aqueous + PVP*

Alcoholic + PVP*

Alcoholic without PVP*

Aqueous + PVP*

Alcoholic + PVP*

Alcoholic without PVP*

Mean tablet weight (mg)

494

480

476

129

123

120

Hardness (N)

73

65

69

72

60

59

Disintegration time (min)

4

< 1

< 1

5

< 3

< 3

Friability (%)

1.25

ND

2.6

0.7

ND

1.04

Drugs released after 45 min of dissolution test (AQ%/AS%)

92/76

94/83

98/91

100/86

ND

100/106