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Table 3 Bilayer ASAQ tablet formulation for high dosage and low dosage ASAQ tablets

From: The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership

Composition Content
(%w/w)
Quantity (mg/tablet)
Layer 1 (blend no 30154C01 )   high dosage tablet (batch 30154C03) low dosage tablet (batch 30154C04)
   Dry granulated AQH 50.38 352.64 88.16
   Sodium Croscarmellose (AcDiSol) 1.40 9.80 2.45
   Polyvinylpyrrolidone (PVP K30) 1.14 8.00 2.00
   Magnesium stearate 1.32 9.26 2.315
   Silicon dioxide (Aerosil 300) 0.11 0.75 0.1875
   Ca carbonate 7.71 54.00 13.50
   Total layer 1 62.06 434.45 108.61
Layer 2 (blend 30154C03)
   AS 14.29 100.00 25.00
   Polyvinylpyrrolidone (PVP K30) 1.14 8.00 2.00
   Sodium Croscarmellose (AcDiSol) 1.40 9.80 2.45
   Magnesium stearate 0.43 3.00 0.75
   Silicon dioxide (Aerosil 300) 0.11 0.75 0.1875
   Calcium carbonate 7.71 54.00 13.50
   Microcrystalline cellulose 12.86 90.00 22.50
   Total layer 2 37.94 265.55 66.39
   Total 100.00 700.00 175.00