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Table 4 Pharmacotechnical properties of various ASAQ monolayer and bilayer tablet formulations

From: The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership

          30154C01
  Batch n° 20454 30411 30412 30436 30437 30438 30439 layer AQ layer AS
Formulation tablet monolayer bilayer
  granulation wet aq. dry
Blend control Flowability (s/100 g) 5 6 9 11 11 7 11 NA NA
  Hausner index (Vo/Vf) 1.25 1.19 1.21 1.23 1.10 1.20 2.24 1.09 1.41
Tablet control Mass (mg) 589.2 622.6 636.7 623.4 622.6 613.8 624 434.5 265.5
          700
  Hardness (N) 61 80 63 78 68 74 71 46
  Friability (%) 1.50 1.27 1.39 1.80 2.55 2.23 1.79 0.31
  Residual humidity (%) 6 ND* ND** 1.84 1.44 1.19 1.07 1.49 1.31
  Disintegration (min) 3.0 1.8 1.6 1.5 1.4 6.1 4.1 < 1.5
  1. Key: NA: data not available
  2. *Residual humidity not determined, Karl Fischer water content 6.35%.
  3. ** Residual humidity not determined, Karl Fischer water content 6.33%.