| |
Paracetamol-group*
|
Placebo-group*
|
OR with confidence interval**
|
|---|
|
Day 0
|
100% (167/167)
|
100% (171/171)
| |
|
Day 7
|
93.3% (152/163)
|
89.1% (147/165)
|
0.57 (0.24 - 1.33)
|
|
Day 14
|
84.4% (133/147)
|
81.0% (131/144)
|
0.75 (0.41 - 1.35)
|
|
Day 21
|
78.2% (115/124)
|
76.5% (118/124)
|
0.85 (0.51 - 1.42)
|
|
Day 28
|
76.8% (108/110)
|
73.2% (111/116)
|
0.80 (0.49 - 1.30)
|
|
Day 35
|
76.0% (97/98)
|
72.5% (102/103)
|
0.80 (0.49 - 1.29)
|
- The adequate clinical and parasitological response (ACPR) rates in the two treatment groups (see text):
- Excluded due to violation of the protocol: In the paracetamol group 2 and 3 children were treated
- outside the study on day 21 and day 28, respectively. In the placebo-group 3 children were admitted to hospital on the day of inclusion and 1 child was treated outside the study on each of the days 21 and 35.
- *) Cumulative percentages of children with ACPR during follow-up. The number of children with ACPR/total number of children is given in parenthesis (on day 7, children with early treatment failure are included in the denominator).
- **) Cumulative odds ratio of having ACPR in the group treated with placebo in relation to the paracetamol-group (Mantel-Haenszel weighted odds ratio, 95% confidence interval in brackets).
