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Table 4 Per protocol analysis of the effect of treatment with chloroquine 25 mg/kg

From: Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial

  Paracetamol-group* Placebo-group* OR with confidence interval**
Day 0 100% (167/167) 100% (171/171)  
Day 7 93.3% (152/163) 89.1% (147/165) 0.57 (0.24 - 1.33)
Day 14 84.4% (133/147) 81.0% (131/144) 0.75 (0.41 - 1.35)
Day 21 78.2% (115/124) 76.5% (118/124) 0.85 (0.51 - 1.42)
Day 28 76.8% (108/110) 73.2% (111/116) 0.80 (0.49 - 1.30)
Day 35 76.0% (97/98) 72.5% (102/103) 0.80 (0.49 - 1.29)
  1. The adequate clinical and parasitological response (ACPR) rates in the two treatment groups (see text):
  2. Excluded due to violation of the protocol: In the paracetamol group 2 and 3 children were treated
  3. outside the study on day 21 and day 28, respectively. In the placebo-group 3 children were admitted to hospital on the day of inclusion and 1 child was treated outside the study on each of the days 21 and 35.
  4. *) Cumulative percentages of children with ACPR during follow-up. The number of children with ACPR/total number of children is given in parenthesis (on day 7, children with early treatment failure are included in the denominator).
  5. **) Cumulative odds ratio of having ACPR in the group treated with placebo in relation to the paracetamol-group (Mantel-Haenszel weighted odds ratio, 95% confidence interval in brackets).