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Figure 2 | Malaria Journal

Figure 2

From: Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Figure 2

Maximum whole (A) and free (B) brain concentrations for racemic mefloquine, + erythro mefloquine, (-) erythro mefloquine and 25novel quinoline methanols after IV dosing to male FVB mice (5 mg/kg). Compounds are color-coded green, yellow or red based on whether they exhibited the desired (> ten-fold lower than racemic mefloquine), acceptable (> five-fold lower than racemic mefloquine) or unacceptable brain levels, respectively.

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