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Table 1 Ranges of physiochemical properties of quinoline methanols investigated in this study.

From: Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Parameter

Range

MW

324-475

cLogD (PP)

1.0-5.2

cLogD (ACD)

-2.3-3.1

PSA (Å2)

36-104

LogP

0.4-3.7

# FRBs

3-11

# HBDs

1-5

# HBAs

3-7

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Malaria Journal

ISSN: 1475-2875

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