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Table 2 Utility of MDCK permeability screen for ranking maximum brain concentrations of quinoline methanols relative to mefloquine.*

From: Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

 

Compounds with Papp < 7.4 × 10-6 cm/s

Compounds with Papp > 7.4 × 10-6 cm/s

Compounds with lower maximum brain concentrations than mefloquine

10

4

Compounds with higher maximum brain concentrations than mefloquine

0

10

  1. * Racemic mefloquine and isomers excluded
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Malaria Journal

ISSN: 1475-2875

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