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Table 2 Utility of MDCK permeability screen for ranking maximum brain concentrations of quinoline methanols relative to mefloquine.*

From: Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

  Compounds with Papp < 7.4 × 10-6 cm/s Compounds with Papp > 7.4 × 10-6 cm/s
Compounds with lower maximum brain concentrations than mefloquine 10 4
Compounds with higher maximum brain concentrations than mefloquine 0 10
  1. * Racemic mefloquine and isomers excluded