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Table 2 QN susceptibility and frequency of pfnhe- 1 haplotype 7 among the three geographical districts

From: Polymorphism of Plasmodium falciparum Na+/H+ exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam

District

Median QN IC50 (nM)

[interquartile range]

Percentage of QNR isolates (n/N)

Percentage of haplotype 7 (n 1 /N 1 )

Dak R'Lap

535[418-849]

28.6 (2/7)

46.7 (7/15)*

Bu Dang

618[450-906]

37.5 (12/32)

72.9 (34/48)

Phuoc Long

770[595-986]

50.0 (6/12)

93.7 (15/16)

  1. 1. n = number of QNR parasite isolates; N = number of parasite isolates with QN IC50.
  2. 2. n1 = total number of parasite isolates carrying the haplotype 7; N1 = number of parasite isolates genotyped for pfnhe-1.
  3. * The percentage of profile 7 is lower in isolates from Dak R'Lap district than that of isolates from Bu Dang or Phuoc Long districts (p < 0.01).