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Table 1 Comparison of biochemical and kinetic properties of protozoan and mammalian hexose transporters

From: Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

  Properties of hexose transport in parasites or host membranes Characterization of hexose transporters genes in heterologous systems (Xenopus oocytes, CHO cells, Δlmgt) Inhibition by compound 3361 Ki(mM) Inhibition of glucose uptake by D-glucose analogues: important carbon position Refs
  K m for D-glucose or 2-DOG (mM) K m for D-glucose or 2-DOG (mM) Transport of D-fructose/K m (mM)    
P. falciparum
(PfHT)
~5 mM (6-DOG) 0.97 ± 0.34 +/11.6 0.053 ± 0.02 1,3,6 [18, 30]
P. knowlesi (PkHT1) ND 0.67 ± 0.16 +/5.12 0.108 ± 0.051 3,4,6 [30, 63]
P. vivax
(PvHT)
ND 0.52-0.85 +/5.91-19.03 0.112 ± 0.13 3,4,6 [30, 63]
P. yoelii
(PyHT1)
ND 0.12 ± 0.04 +/2.94 0.080 ± 0.016 3,4,6 [30, 63]
P. berghei
(PbHT)
ND 0.09 ± 0.02 0.54 ~ 0.009 ND [40]
T. gondii (TgGT1) ND 0.030 ± 0.006 + § 2.073 ± 0.59 3,4,6 [63]
B. bovis (BboHT1) ND 0.84 ± 0.50 +/ND 0.005 ± 0.002 4,6 [58]
Leishmania LmGT1 1.22 ± 0.22 ND +/ND ND ND [56]
Leishmania LmGT2 109 ± 22 ND +/ND ND ND [56]
Leishmania LmGT3 208 ± 40 ND +/ND ND ND [56]
T. brucei
THT1
0.5-2.0 ND +/2.56-3.91 ND 3,4 [55, 6466]
T. brucei
THT2
0.038-0.08/2.0 0.151 ± 0.01 +/2.54 ND 3,4,6 [66]
T. vivax
TvHT1
0.585 ± 0.068 0.545 ± 0.02 +/ND ND 1,3,6 [6567]
GLUT1 4-10 ~ 2 - 3.3 ± 0.21 1,4,6 [19, 66]
GLUT5 ND - +/13 ND ND [68]
  1. ND - not determined
  2. § - D-fructose uptake at 37°C
  3. +/ND - transport of fructose observed but Km not determined
  4. Δlmgt - glucose transporter null mutant of Leishmania mexicana
  5. CHO - The Chinese hamster ovary (CHO) cell line