From: Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa
 | Properties of hexose transport in parasites or host membranes | Characterization of hexose transporters genes in heterologous systems (Xenopus oocytes, CHO cells, Δlmgt) | Inhibition by compound 3361 Ki(mM) | Inhibition of glucose uptake by D-glucose analogues: important carbon position | Refs | |
---|---|---|---|---|---|---|
 | K m for D-glucose or 2-DOG (mM) | K m for D-glucose or 2-DOG (mM) | Transport of D-fructose/K m (mM) |  |  |  |
P. falciparum (PfHT) | ~5 mM (6-DOG) | 0.97 ± 0.34 | +/11.6 | 0.053 ± 0.02 | 1,3,6 | |
P. knowlesi (PkHT1) | ND | 0.67 ± 0.16 | +/5.12 | 0.108 ± 0.051 | 3,4,6 | |
P. vivax (PvHT) | ND | 0.52-0.85 | +/5.91-19.03 | 0.112 ± 0.13 | 3,4,6 | |
P. yoelii (PyHT1) | ND | 0.12 ± 0.04 | +/2.94 | 0.080 ± 0.016 | 3,4,6 | |
P. berghei (PbHT) | ND | 0.09 ± 0.02 | 0.54 | ~ 0.009 | ND | [40] |
T. gondii (TgGT1) | ND | 0.030 ± 0.006 | + § | 2.073 ± 0.59 | 3,4,6 | [63] |
B. bovis (BboHT1) | ND | 0.84 ± 0.50 | +/ND | 0.005 ± 0.002 | 4,6 | [58] |
Leishmania LmGT1 | 1.22 ± 0.22 | ND | +/ND | ND | ND | [56] |
Leishmania LmGT2 | 109 ± 22 | ND | +/ND | ND | ND | [56] |
Leishmania LmGT3 | 208 ± 40 | ND | +/ND | ND | ND | [56] |
T. brucei THT1 | 0.5-2.0 | ND | +/2.56-3.91 | ND | 3,4 | |
T. brucei THT2 | 0.038-0.08/2.0 | 0.151 ± 0.01 | +/2.54 | ND | 3,4,6 | [66] |
T. vivax TvHT1 | 0.585 ± 0.068 | 0.545 ± 0.02 | +/ND | ND | 1,3,6 | |
GLUT1 | 4-10 | ~ 2 | - | 3.3 ± 0.21 | 1,4,6 | |
GLUT5 | ND | - | +/13 | ND | ND | [68] |