Skip to main content

Table 1 Anti-plasmodial activity and cytotoxicity of sub-extracts and fractions from H. lanceolatum

From: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Sub-extract or Fraction IC50 on W2mef (μg/mL) CC50 on LLC-MK2 cells (μg/mL) Selectivity Index (SI)
MeOH crude extract 3.98 ± 0.11 > 1000 -
Ethylacetate sub-extract 5.02 ± 1.01 204.86 ± 2.00 40.80 ± 0.39
Aqueous sub-extract 15.48 ± 6.25 125 ± 0.00 8.07 ± 0.00
n -butanol extract 11.95 ± 5.81 >1000 -
F1 15.60 ± 1.35 46.87 ± 15.62 3.00 ± 1.00
F2 6.37 ± 2.17 125 ± 0.00 19.62 ± 0.00
F3 3.91 ± 0.01 250 ± 0.00 39.24 ± 0.00
F4 5.33 ± 2.47 31.25 ± 0.00 5.86 ± 0.00
F5 14.52 ± 0.46 >1000 -
QN 0.27 ± 0.04 - -
  1. QN: Quinine