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Table 1 Anti-plasmodial activity and cytotoxicity of sub-extracts and fractions from H. lanceolatum

From: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Sub-extract or Fraction

IC50 on W2mef (μg/mL)

CC50 on LLC-MK2 cells (μg/mL)

Selectivity Index (SI)

MeOH crude extract

3.98 ± 0.11

> 1000

-

Ethylacetate sub-extract

5.02 ± 1.01

204.86 ± 2.00

40.80 ± 0.39

Aqueous sub-extract

15.48 ± 6.25

125 ± 0.00

8.07 ± 0.00

n -butanol extract

11.95 ± 5.81

>1000

-

F1

15.60 ± 1.35

46.87 ± 15.62

3.00 ± 1.00

F2

6.37 ± 2.17

125 ± 0.00

19.62 ± 0.00

F3

3.91 ± 0.01

250 ± 0.00

39.24 ± 0.00

F4

5.33 ± 2.47

31.25 ± 0.00

5.86 ± 0.00

F5

14.52 ± 0.46

>1000

-

QN

0.27 ± 0.04

-

-

  1. QN: Quinine