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Table 2 Extraction yield and anti-plasmodial activity of pure compounds isolated from H. lanceolatum

From: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Compound (code) Quantity (mg) Extraction yield IC50 on W2mef (μM) IC50 on SHF4 (μM)
HLT0 8 0.07 4.26 ± 0.15* 5.89 ± 0.20*
Betulinic acid (HLT1) 90 2.0 4.50 ± 1.35 5.60 ± 0.13
2,2',5,6'-Tetrahydroxybenzophenone (HLT2) 150 3.33 55.12 ± 0.93 13.41 ± 0.16
5-Hydroxy-3-methoxyxanthone (HLT3) 9 0.06 3.26 ± 0.08 1.43 ± 0.48
3-Hydroxy-5-methoxyxanthone (HLT4) 30 0.11 33.84 ± 0.20 34.09 ± 0.12
QN - - 0.27 ± 0.04 0.14 ± 0.05
  1. *IC50 expressed in μg/mL; Extraction yield expressed in % weight/weight of the ethylacetate fraction