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Table 3 Cytotoxicity profile of H. Lanceolatum compounds

From: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Compound (code) CC50 on LLC-MK2 (μg/mL) Mean SI for W2mef Mean SI for W2mef
HLT0 37.50 ± 6.25 7.48 6.27
Betulinic acid (HLT1) 25.00 ± 0.00 4.98 4.46
2,2',5,6'-Tetrahydroxybenzophenone (HLT2) > 100 - -
5-Hydroxy-3-methoxyxanthone (HLT3) > 100 - -
3-Hydroxy-5-methoxyxanthone (HLT4) 12.50 ± 0.00 0.36 ± 0.00 0.36
  1. Cytotoxicity was categorised as follows [15]: CC50 < 1.0 μg/ml (high cytotoxicity); CC50 1.0 -10.0 μg/ml (moderate); CC50 10.0-30.0 μg/ml (mild); and CC50 > 30 μg/ml (non toxic).