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Figure 5 | Malaria Journal

Figure 5

From: Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

Figure 5

IT/R29 var gene transcription in rosetting versus non-rosetting parasites analysed by VSA-supplemented microarray. (A) Colour legend used for the microarray data. (B) Each row represents one var gene and values from multiple oligos specific to the same gene were averaged. Each var gene is represented by 2 to 5 oligos on the chip, with an oligo approximately every 2 kb for each gene. Each column is a time point with 8-hour intervals. Var gene names and groups (A, B or C) are as described previously [40, 41]. Data represented are the expression ratio of data from IT/R29R+ over IT/R29R-, thus red squares indicate higher amount of cDNA in the IT/R29R+ compared to the IT/R29R- population, and green squares indicate less cDNA in IT/R29R+ than IT/R29R-. A grey square indicates the lack of data (expression intensity below background level). Var genes with expression intensity below background level at all time points are not shown. ITvar9 is up-regulated in IT/R29R+ by 19, 21, 115, 57, 109 and 439 fold from time point 1 to 6, respectively.

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Malaria Journal

ISSN: 1475-2875

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