
Nonpregnant adults

Pregnant women^{♭,♮}


Model &Parameter*^{,§}

Estimate^{†} (95% CI)^{◇}

Estimate^{‡} (95% CI)^{◇}

Estimate^{†} (95% CI)^{◇}


Bateman model
   
k_{
a
} (/h)

0.82 (0.76, 0.87)

0.89 (0.81, 0.97)

1.19 (0.78, 1.60)

CL/F (L/h)

47.5 (44.6, 50.4)

48.8 (42.3, 55.3)

88.5 (60, 117)

V/F (L)

32.1 (24.6, 39.6)

44.4 (30.2, 58.6)

232 (57.0, 406)

t_{
lag
} (h)

0.21 (fixed)

n/a

0.42 (0.34, 0.50)


26.7

11.4

not reported

Ω_{
CL
}_{/}_{
F
}

29.4

26.8

47.0

Ω_{
V
}_{/}_{
F
}

81.9

64.7

154


10.0

n/a

not reported

Ω_{
CL
}_{/}_{
F
},_{
V
}_{/}_{
F
}

0.58

0.75

not reported


0.19

n/a

not reported

σ

0.41

0.55

not reported

Dost model
   
k (/h)

0.99 (0.91, 1.1)

0.95 (0.86, 1.03)
 
V/F (L)

46.3 (37.6, 55.0)

51.3 (41.2, 61.4)
 
t_{
lag
} (h)

0.21 (fixed)

n/a
 
Ω_{
k
}

22.0

20.8
 
Ω_{
V
}/_{
F
}

48.2

42.2
 

11.4

n/a
 
Ω_{
k
}_{,}_{
V
}/_{
F
}

0.79

0.81
 
σ

0.47

0.57
 
 *The Ω's represent betweensubject variances and covariances, expressed as the percent coefficient of variation (%CV, approximated by the square root of the variance estimate multiplied by 100) and correlation coefficients, respectively
 ^{§}The σ's represent residual standard deviations (proportional)
 ^{♭}Taken from McGready et al. [5]
 ^{♮}Reported CL/F (L/kg/h) and V/F (L/kg) multiplied by median weight (50 kg)
 ^{†}Lagtime included
 ^{‡}Lagtime not included
 ^{◇}Upper and lower bounds of CIs were considered for the PK parameters only