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Table 1 Population pharmacokinetic models and parameter values for the non-pregnant adults and pregnant women designs

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

 

Non-pregnant adults

Pregnant womenâ™­,â™®

Model &Parameter*,§

Estimate† (95% CI)◇

Estimate‡ (95% CI)◇

Estimate† (95% CI)◇

Bateman model

   

k a (/h)

0.82 (0.76, 0.87)

0.89 (0.81, 0.97)

1.19 (0.78, 1.60)

CL/F (L/h)

47.5 (44.6, 50.4)

48.8 (42.3, 55.3)

88.5 (60, 117)

V/F (L)

32.1 (24.6, 39.6)

44.4 (30.2, 58.6)

232 (57.0, 406)

t lag (h)

0.21 (fixed)

n/a

0.42 (0.34, 0.50)

26.7

11.4

not reported

Ω CL / F

29.4

26.8

47.0

Ω V / F

81.9

64.7

154

10.0

n/a

not reported

Ω CL / F , V / F

0.58

0.75

not reported

0.19

n/a

not reported

σ

0.41

0.55

not reported

Dost model

   

k (/h)

0.99 (0.91, 1.1)

0.95 (0.86, 1.03)

 

V/F (L)

46.3 (37.6, 55.0)

51.3 (41.2, 61.4)

 

t lag (h)

0.21 (fixed)

n/a

 

Ω k

22.0

20.8

 

Ω V / F

48.2

42.2

 

11.4

n/a

 

Ω k , V / F

-0.79

-0.81

 

σ

0.47

0.57

 
  1. *The Ω's represent between-subject variances and covariances, expressed as the percent coefficient of variation (%CV, approximated by the square root of the variance estimate multiplied by 100) and correlation coefficients, respectively
  2. §The σ's represent residual standard deviations (proportional)
  3. â™­Taken from McGready et al. [5]
  4. â™®Reported CL/F (L/kg/h) and V/F (L/kg) multiplied by median weight (50 kg)
  5. †Lag-time included
  6. ‡Lag-time not included
  7. â—‡Upper and lower bounds of CIs were considered for the PK parameters only
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Malaria Journal

ISSN: 1475-2875

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