Skip to main content

Advertisement

Table 2 Optimal sampling times and sampling windows from POPT for each design

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

Design Optimal times (sampling windows)
Non-pregnant adults* (n = 60) 20 min (17 to 29 min) 35 min (30 to 57 min) 3.0 h (2.5 to 3.7 h) 6.2 h (5.8 to 6.6 h)
Non-pregnant adults and children* <2 y (n = 10): 19 min (16 to 28 min) 2.3 h (2.0 to 2.8 h) 5.8 h (5.5 to 6.1 h)  
2-10 y (n = 10): 19 min (16 to 26 min) 34 min (31 min to 1.0 h) 5.76 h (5.5 to 6.2 h)  
11-20 y (n = 10): 20 min (17 to 29 min) 2.2 h (2.1 to 3.0 h) 6.1 h (5.6 to 6.5 h)  
>20 y (n = 30): 20 min (18 to 27 min) 2.5 h (2.2 to 2.7 h) 2.8 h (2.7 to 3.4 h) 6.1 h (5.9 to 6.6 h)
Pregnant women*,†,‡ (n = 60) 43 min (35 to 59 min) 3.3 h (1.2 to 3.4 h) 3.5 h (3.4 to 4.9 h) 7.4 h (6.0 to 8.0 h)
  1. *For structural models with a lag-time, the lag-time parameter and its BSV were specified in POPT to not be estimated
  2. The BSV of k a was set to that of the non-pregnant adults and the BSV of V/F was reduced to 1
  3. Competing values of the BSV of V/F were set to 0.67 (derived from the results of the non-compartmental analysis in [5]) and 2.37 (the reported BSV from the population PK analysis in [5])