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Table 2 Optimal sampling times and sampling windows from POPT for each design

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

Design Optimal times
(sampling windows)
Non-pregnant adults*
(n = 60)
20 min
(17 to 29 min)
35 min
(30 to 57 min)
3.0 h
(2.5 to 3.7 h)
6.2 h
(5.8 to 6.6 h)
Non-pregnant adults and children*
<2 y (n = 10):
19 min
(16 to 28 min)
2.3 h
(2.0 to 2.8 h)
5.8 h
(5.5 to 6.1 h)
 
2-10 y (n = 10): 19 min
(16 to 26 min)
34 min
(31 min to 1.0 h)
5.76 h
(5.5 to 6.2 h)
 
11-20 y (n = 10): 20 min
(17 to 29 min)
2.2 h
(2.1 to 3.0 h)
6.1 h
(5.6 to 6.5 h)
 
>20 y (n = 30): 20 min
(18 to 27 min)
2.5 h
(2.2 to 2.7 h)
2.8 h
(2.7 to 3.4 h)
6.1 h
(5.9 to 6.6 h)
Pregnant women*,†,‡
(n = 60)
43 min
(35 to 59 min)
3.3 h
(1.2 to 3.4 h)
3.5 h
(3.4 to 4.9 h)
7.4 h
(6.0 to 8.0 h)
  1. *For structural models with a lag-time, the lag-time parameter and its BSV were specified in POPT to not be estimated
  2. The BSV of k a was set to that of the non-pregnant adults and the BSV of V/F was reduced to 1
  3. Competing values of the BSV of V/F were set to 0.67 (derived from the results of the non-compartmental analysis in [5]) and 2.37 (the reported BSV from the population PK analysis in [5])