|
k
a
|
CL/F
|
V/F
|
t
lag
|
|
Ω
CL
/
F
|
Ω
V
/
F
|
σ
|
---|
Non-pregnant adults
| | | | | | | | |
Optimal design
| | | | | | | | |
POPT*
|
5.44
|
3.73
|
10.15
|
-
|
45.5
|
22.2
|
17.5
|
4.98
|
Simulation-estimation†,‡
|
10.7
|
5.99
|
17.3
|
6.86
|
52.9
|
30.7
|
21.6
|
7.87
|
Non-pregnant adults and children
| | | | | | | | |
Optimal design
| | | | | | | | |
POPT*
|
5.14
|
3.81
|
10.4
|
-
|
42.5
|
23.6
|
19.0
|
5.83
|
Simulation-estimation†,‡
|
8.97
|
5.63
|
22.7
|
9.88
|
55.2
|
37.4
|
29.2
|
8.52
|
Pregnant women
| | | | | | | | |
Optimal design
| | | | | | | | |
POPT*
|
8.22
|
4.76
|
10.5
|
-
|
-
|
15.9
|
14.7
|
4.20
|
Simulation-estimation†,#
|
14.7
|
8.28
|
17.5
|
8.67
|
-
|
27.0
|
25.8
|
7.33
|
- *Expected %RSEs
- †Empirical %RSEs
- ‡
fixed
- #
and
fixed