| k a | CL/F | V/F | t lag |
| Ω CL / F | Ω V / F | σ |
---|---|---|---|---|---|---|---|---|
Non-pregnant adults | Â | Â | Â | Â | Â | Â | Â | Â |
Optimal design | Â | Â | Â | Â | Â | Â | Â | Â |
POPT* | 5.44 | 3.73 | 10.15 | - | 45.5 | 22.2 | 17.5 | 4.98 |
Simulation-estimation†,‡ | 10.7 | 5.99 | 17.3 | 6.86 | 52.9 | 30.7 | 21.6 | 7.87 |
Non-pregnant adults and children | Â | Â | Â | Â | Â | Â | Â | Â |
Optimal design | Â | Â | Â | Â | Â | Â | Â | Â |
POPT* | 5.14 | 3.81 | 10.4 | - | 42.5 | 23.6 | 19.0 | 5.83 |
Simulation-estimation†,‡ | 8.97 | 5.63 | 22.7 | 9.88 | 55.2 | 37.4 | 29.2 | 8.52 |
Pregnant women | Â | Â | Â | Â | Â | Â | Â | Â |
Optimal design | Â | Â | Â | Â | Â | Â | Â | Â |
POPT* | 8.22 | 4.76 | 10.5 | - | - | 15.9 | 14.7 | 4.20 |
Simulation-estimation†,# | 14.7 | 8.28 | 17.5 | 8.67 | - | 27.0 | 25.8 | 7.33 |