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Table 3 Expected and empirical percent relative standard errors (%RSEs) for the Bateman model assuming the optimal designs

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

  k a CL/F V/F t lag Ω CL / F Ω V / F σ
Non-pregnant adults         
Optimal design         
POPT* 5.44 3.73 10.15 - 45.5 22.2 17.5 4.98
Simulation-estimation†,‡ 10.7 5.99 17.3 6.86 52.9 30.7 21.6 7.87
Non-pregnant adults and children         
Optimal design         
POPT* 5.14 3.81 10.4 - 42.5 23.6 19.0 5.83
Simulation-estimation†,‡ 8.97 5.63 22.7 9.88 55.2 37.4 29.2 8.52
Pregnant women         
Optimal design         
POPT* 8.22 4.76 10.5 - - 15.9 14.7 4.20
Simulation-estimation†,# 14.7 8.28 17.5 8.67 - 27.0 25.8 7.33
  1. *Expected %RSEs
  2. †Empirical %RSEs
  3. ‡ fixed
  4. # and fixed
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