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Table 3 Expected and empirical percent relative standard errors (%RSEs) for the Bateman model assuming the optimal designs

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

 

k a

CL/F

V/F

t lag

Ω CL / F

Ω V / F

σ

Non-pregnant adults

        

Optimal design

        

POPT*

5.44

3.73

10.15

-

45.5

22.2

17.5

4.98

Simulation-estimation†,‡

10.7

5.99

17.3

6.86

52.9

30.7

21.6

7.87

Non-pregnant adults and children

        

Optimal design

        

POPT*

5.14

3.81

10.4

-

42.5

23.6

19.0

5.83

Simulation-estimation†,‡

8.97

5.63

22.7

9.88

55.2

37.4

29.2

8.52

Pregnant women

        

Optimal design

        

POPT*

8.22

4.76

10.5

-

-

15.9

14.7

4.20

Simulation-estimation†,#

14.7

8.28

17.5

8.67

-

27.0

25.8

7.33

  1. *Expected %RSEs
  2. †Empirical %RSEs
  3. ‡ fixed
  4. # and fixed