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Table 4 Expected and empirical percent relative standard errors (%RSEs) for the Dost model assuming the optimal designs

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

 

k

V/F

t lag

Ω k

Ω V / F

σ

Non-pregnant adults

      

Optimal design

      

POPT*

2.32

5.06

-

16.7

17.3

4.31

Simulation-estimation †‡

4.33

8.05

8.77

24.7

19.4

7.46

  1. *Expected %RSEs
  2. †Empirical %RSEs
  3. ‡ fixed