From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria
k
V/F
t lag
Ω k
Ω V / F
σ
Non-pregnant adults
Optimal design
POPT*
2.32
5.06
-
16.7
17.3
4.31
Simulation-estimation †‡
4.33
8.05
8.77
24.7
19.4
7.46