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Table 4 Expected and empirical percent relative standard errors (%RSEs) for the Dost model assuming the optimal designs

From: Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

  k V/F t lag Ω k Ω V / F σ
Non-pregnant adults       
Optimal design       
POPT* 2.32 5.06 - 16.7 17.3 4.31
Simulation-estimation 4.33 8.05 8.77 24.7 19.4 7.46
  1. *Expected %RSEs
  2. Empirical %RSEs
  3. fixed