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Figure 4 | Malaria Journal

Figure 4

From: Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques

Figure 4

Protein sequence (aa 25 - 545) alignments for DiCo antigens and parasite AMA1 alleles. AMA1 protein sequences of malaria parasites used for in vitro growth inhibition assays were accessed from the GenBank database. The DiCo sequences contain point mutations at the cleavage (K376R, indicated in orange) and potential N-glycosylation (N162Q, T288V, S373D, N422D, S423K, N499Q, indicated in red) sites and differ from parasite AMA1 sequences at these sites. Amino acid residues 25 to 96 represent the prodomain of the AMA1 transmembrane protein, residues 97 - 303 represent domain I, residues 304 - 440 represent domain II and residues 441 - 545 represent domain III of the protein ectodomain.

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Malaria Journal

ISSN: 1475-2875

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