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Table 6 Changes in individuals' biochemical indices used to assess tolerability

From: Comparative study of the efficacy and tolerability of dihydroartemisinin - piperaquine - trimethoprim versus artemether - lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal

Parameters

DPT

AL

P**

 

D1

D7

D1-D7

p*

D1

D7

D1-D7

p*

 

ASAT

(SD) IU/l

30.53

(21.79)

28.83

(10.9)

1.7

(21.87)

0.271

31.25

(18.81)

32.69

(21.9)

-1.44

(28.52)

0.492

0.223

ALAT

(SD) IU/l

25.75

(20.46)

25.74

(12.51)

0.01

(20.77)

0.997

28.32

(16.46)

28.63

(17.82)

-0.31

(23.94)

0.861

0.888

Creatinine

(SD) mg/l

8.31

(2.39)

8.15

(2.46)

0.16

(2.59)

0.400

8.31

(2.46)

8.37

(2.47)

-0.06

(2.88)

0.799

0.430

Bilirubin

(SD) mg/l

9.52

(7.56)

7.68

(4.11)

1.84

(8.74)

0.003

10.75

(11.03)

7.71

(3.69)

3.04

(11.68)

0.000

0.245

  1. *paired t test.
  2. ** t test for independent samples comparing drop within individuals'values in DPT and AL groups.