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Table 2 In vitro drug sensitivity of Plasmodium falciparum isolates, N = 31

From: Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro

Anti- malaria drug Number of isolates (%) IC50 value (nM)
  Sensitive Resistant* Lowest/Highest Geometric mean
(CI) 		Standard deviation
(CI)
Artesunate 31 (100) 0 (0) 0.2/3.6 0.73
(0.38-1.08) 		0.95
(0.76-1.27)
Amodiaquine 22 (71.0) 9 (29.0) 2.0/162.0 30.69
(14.18-47.20) 		45.00
(35.96-60.15)
Chloroquine 15 (48.4) 16 (51.6) 2.0/200.0 58.73
(38.08-79.38) 		56.30
(44.99-75.25)
Quinine 25 (80.6) 6 (19.4) 15.0/990.0 355.37
(250.48-460.26) 		285.95
(228.50-382.22)
  1. *IC50 threshold for resistance are amodiaquine 60 nM, chloroquine 100 nM and quinine 800 nM. Studies on sensitivity cut-off point for artemisinin and its derivative is not conclusive yet but an IC50 of 20 nM is considered high [28, 29]. Thirty-eight (38) samples were tested, out of which 31 (81.6%) were successfully phenotyped with the anti-malaria drugs. Test was successful when percentage of schizont to total parasite in drug-free control well was at least 10%. Confidence interval (CI) is at 0.05 significance level.
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Malaria Journal

ISSN: 1475-2875

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