Anti- malaria drug | Number of isolates (%) | IC50 value (nM) |
---|
 | Sensitive | Resistant* | Lowest/Highest | Geometric mean (CI) | Standard deviation (CI) |
---|
Artesunate | 31 (100) | 0 (0) | 0.2/3.6 | 0.73 (0.38-1.08) | 0.95 (0.76-1.27) |
Amodiaquine | 22 (71.0) | 9 (29.0) | 2.0/162.0 | 30.69 (14.18-47.20) | 45.00 (35.96-60.15) |
Chloroquine | 15 (48.4) | 16 (51.6) | 2.0/200.0 | 58.73 (38.08-79.38) | 56.30 (44.99-75.25) |
Quinine | 25 (80.6) | 6 (19.4) | 15.0/990.0 | 355.37 (250.48-460.26) | 285.95 (228.50-382.22) |
- *IC50 threshold for resistance are amodiaquine 60 nM, chloroquine 100 nM and quinine 800 nM. Studies on sensitivity cut-off point for artemisinin and its derivative is not conclusive yet but an IC50 of 20 nM is considered high [28, 29]. Thirty-eight (38) samples were tested, out of which 31 (81.6%) were successfully phenotyped with the anti-malaria drugs. Test was successful when percentage of schizont to total parasite in drug-free control well was at least 10%. Confidence interval (CI) is at 0.05 significance level.