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Table 4 SNPs and their corresponding amino acid point mutations in pfATPase6 gene, N = 68

From: Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro

SNP Point mutation Frequency (%) Artesunate IC50 (nM)
GGC D639G 34 (50.0) 0.2 - 3.6*
AAA E431K 7 (10.3) 0.6 - 3.6
GAA D443E 5 (7.4) 0.6*
CAA M813Q 5 (7.4) 0.6 - 0.9
CAT Q622H 3 (4.4) 0.3 - 3.6
GTA L402V 2 (2.9) 0.3 - 2.6
TTA F414L 2 (2.9) 0.4 - 0.8
AAT D419N 2 (2.9) 0.3
TAT C356Y 1 (1.5) 1.4
AAA R377K 1 (1.5) NA
AAA E384K 1 (1.5) NA
AAA T403K 1 (1.5) 0.2
GAA D405E 1 (1.5) 1.7
ACT A425T 1 (1.5) NA
AAA E432K 1 (1.5) NA
TCT A630S 1 (1.5) NA
GGT C645G 1 (1.5) 0.5
GGA E696G 1 (1.5) NA
AAA E710K 1 (1.5) 0.4
GGT D734G 1 (1.5) NA
  1. *Some isolates of the corresponding nucleotide were not phenotyped, just as NA (not applicable) represents isolates that were not phenotyped.