Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro

Table 4 SNPs and their corresponding amino acid point mutations in pfATPase6 gene, N = 68

SNP	Point mutation	Frequency (%)	Artesunate IC₅₀ (nM)
GGC	D639G	34 (50.0)	0.2 - 3.6^*
AAA	E431K	7 (10.3)	0.6 - 3.6
GAA	D443E	5 (7.4)	0.6^*
CAA	M813Q	5 (7.4)	0.6 - 0.9
CAT	Q622H	3 (4.4)	0.3 - 3.6
GTA	L402V	2 (2.9)	0.3 - 2.6
TTA	F414L	2 (2.9)	0.4 - 0.8
AAT	D419N	2 (2.9)	0.3
TAT	C356Y	1 (1.5)	1.4
AAA	R377K	1 (1.5)	NA
AAA	E384K	1 (1.5)	NA
AAA	T403K	1 (1.5)	0.2
GAA	D405E	1 (1.5)	1.7
ACT	A425T	1 (1.5)	NA
AAA	E432K	1 (1.5)	NA
TCT	A630S	1 (1.5)	NA
GGT	C645G	1 (1.5)	0.5
GGA	E696G	1 (1.5)	NA
AAA	E710K	1 (1.5)	0.4
GGT	D734G	1 (1.5)	NA

*Some isolates of the corresponding nucleotide were not phenotyped, just as NA (not applicable) represents isolates that were not phenotyped.

ISSN: 1475-2875