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Table 1 IC50 values for oxidative stress inducers and an aminotransferase inhibitor for D10 and D10Δgdhaclones

From: Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

   IC50values (μM)  
Parasite line N-methylphenazonium methosulfate Tert -butylhydroperoxide L-cycloserine
D10 0.8 ± 0.2 76.7 ± 20.0 145.8 ± 56.6
D10Δgdha-1 0.7 ± 0.2 81.8 ± 17.2 113.5 ± 37.5
D10Δgdha-2 0.7 ± 0.1 81.3 ± 15.5 111.9 ± 37.4
  1. The effect on parasite viability by the endogenous stressor N-methylphenazonium methosulfate, the exogenous stressor tert-butylhydroperoxide and the aminotransferase inhibitor L-cycloserine were determined by the incorporation of [3H]-hypoxanthine in the presence of increasing drug concentrations. The IC50 values were calculated by non linear regressing of the sigmoidal dose-response equation and shown are the mean ± S.D. of two (N-methylphenazonium methosulfate) or three (tert-butylhydroperoxide) independent experiments. For L-cycloserine the mean ± S.E.M of six independent experiments is shown.
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Malaria Journal

ISSN: 1475-2875

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