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Table 1 Summary of World Health Organization (2010) and Government of Kenya (2005 and 2010) clinical practice guidelines for the management of children with severe malaria

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

Treatment for children aged < 5 years with a diagnosis of severe malaria GoK 2005
Basic Paediatric Protocols*
GoK 2010 Malaria Case Management Guidelines WHO 2010 Malaria Case Management Guidelines
Pre-referral quinine loading dose 15 mg/kg IM injection 20 mg/kg IM injection 20 mg/kg IM injection
First-line treatment with quinine dose 15 mg/kg loading dose then 10 mg/kg every 12 hours by IV infusion or divided IM injection 20 mg/kg loading dose then 10 mg/kg every 8 hours by IV infusion or divided IM injection 20 mg/kg loading dose then 10 mg/kg every 8 hours by IV infusion or
divided IM injection
  1. *Based on 1998 DoMC Malaria Treatment Guidelines.