Table 2 Study selection inclusion/exclusion criteria

P. falciparum malaria

Uncomplicated malaria

Randomized Controlled Trials (observational studies to be considered if no RCT evidence)

IR administration

Children < 5 years old (older children and adult data to be considered if no studies in children)

Diagnosis of severe or complicated malaria, confirmed with microscopy or rapid diagnostic test or cerebral malaria

African setting

IM or IV administration