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Table 4 Characteristics of studies that evaluated quinine loading dose (Systematic review 1)

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

    Test quinine sulphate dose (IV) Comparator quinine sulphate dose (IV)
Study Age range Country Loading dose Maintenance dose Uniform dose
Assimadi 2002* (N = 72) 8 months to 15 years Benin 21 mg/kg 10.5 mg/kg every 12 hours 15.9 mg/kg every 12 hours
Fargier 1991* (N = 20) 15 years and above Cameroon 19 mg/kg 9.7 mg/kg every 8 hours 9.7 mg/kg every 8 hours
Pasvol 1991# (N = 59) up to 12 years Kenya 20 mg/kg 10 mg/kg every 12 hours 5 to 10 mg/kg every 12 hours
Tombe 1992 (N = 33) 14 years and above Kenya 20 mg/kg 10 mg/kg every 8 hours 10 mg/kg every 8 hours
  1. *Reported quinine doses converted from quinine base to quinine salt using salt conversion factor of 1.21
  2. #N = 20 patients who received IM quinine were excluded from this analysis
  3. Adapted from Lesi et al 2004 Cochrane systematic review [9]