Skip to main content

Table 6 Pharmacokinetic parameters of IV and IM administered quinine in African children (Systematic review 3b)

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

Study ID
(sample size)
Evidence
Quality
Route of admn Sample size per arm Quinine loading dose Quinine maintenance dose Infusion time Cmax (mg/l) tmax (h) t1/2 (h) Cl (ml/min/kg) Vd (l/kg) AUC (mg/l/h)
Pasvol 1991 (N = 43) Low IV n = 21 10 mg/kg 5 mg/kg 2 h 9.7 ± 5.3 2.7 ± 1.3 8.9 ± 4.0 1.36 ± 0.58 0.87 ± 0.27 145 ± 61
Winstanley 1993
(N = 22)
Very
Low
IV n = 12 14 mg/kg 10 mg/kg bd 2 h 13.8 ± 3.1 - 16.4 ± 8.8 0.45 ± 0.13 0.45 ± 0.10  
Winstanley 1994 (N = 9) Very
Low
IV n = 9 15 mg/kg 10 mg/kg bd 2 h 17.9 ± 2.9 - 12.6 ± 3.1 0.81 ± 0.24 0.75 ± 0.11  
Pasvol 1991 (N = 43) Low IV n = 18 20 mg/kg 10 mg/kg bd 2 h 15.3 ± 5.5 2.4 ± 1.5 12.5 ± 3.2 1.19 ± 0.29 1.22 ± 0.16 254 ± 86
van Hensbroek 1996 (N = 16) Very
Low
IV n = 6 20 mg/kg 10 mg/kg bd 4 h 17.48 ± 2.43 - 13.16 ± 6.43 0.51 ± 0.16 1.04 ± 0.21 354 ± 143
Waller 1990 (N = 21) Very
Low
IM n = 21 20 mg/kg 10 mg/kg bd N/A 15.4 ± 4.5 3.23 ± 1.63 18.8 ± 8.0 0.89 ± 0.81 - 449 ± 243
Pasvol 1991 (N = 43) Low IM n = 20 20 mg/kg 10 mg/kg bd N/A 15.3 ± 7.6 2.4 ± 1.7 15.7 ± 8.2 1.12 ± 0.56 1.22 ± 0.32 332 ± 254
Winstanley 1993 (N = 22) Very
Low
IM n = 10 20 mg/kg 10 mg/kg bd N/A 15.7 ± 3.1 1.6 ± 1.7 - - - -
van Hensbroek 1996 (N = 16) Very
Low
IM n = 10 20 mg/kg 10 mg/kg bd N/A 16.36 ± 3.67 1.08 ± 0.37 15.31 ± 7.16 0.59 ± 0.25 1.32 ± 0.49 358 ± 164
Krishna 2001 (N = 120) Very
Low
IM n = 120 20 mg/kg 10 mg/kg bd N/A - - 19.9 ± 4.4 0.05 - -
  1. Legend:
  2. Cmax (mg/l): Maximum circulating concentration
  3. tmax (h): Time at maximum circulating concentration
  4. t1/2 (h): Half-life
  5. Cl (ml/min/kg): Clearance
  6. Vd (l/kg): Volume of distribution
  7. AUC (mg/l/h): Area under the curve.