Table 6 Pharmacokinetic parameters of IV and IM administered quinine in African children (Systematic review 3b)

Pasvol 1991 (N = 43)

Low

IV

n = 21

10 mg/kg

5 mg/kg

2 h

9.7 ± 5.3

2.7 ± 1.3

8.9 ± 4.0

1.36 ± 0.58

0.87 ± 0.27

145 ± 61

Winstanley 1993

(N = 22)

Very

Low

IV

n = 12

14 mg/kg

10 mg/kg bd

2 h

13.8 ± 3.1

-

16.4 ± 8.8

0.45 ± 0.13

0.45 ± 0.10

Winstanley 1994 (N = 9)

Very

Low

IV

n = 9

15 mg/kg

10 mg/kg bd

2 h

17.9 ± 2.9

-

12.6 ± 3.1

0.81 ± 0.24

0.75 ± 0.11

Pasvol 1991 (N = 43)

Low

IV

n = 18

20 mg/kg

10 mg/kg bd

2 h

15.3 ± 5.5

2.4 ± 1.5

12.5 ± 3.2

1.19 ± 0.29

1.22 ± 0.16

254 ± 86

van Hensbroek 1996 (N = 16)

Very

Low

IV

n = 6

20 mg/kg

10 mg/kg bd

4 h

17.48 ± 2.43

-

13.16 ± 6.43

0.51 ± 0.16

1.04 ± 0.21

354 ± 143

Waller 1990 (N = 21)

Very

Low

IM

n = 21

20 mg/kg

10 mg/kg bd

N/A

15.4 ± 4.5

3.23 ± 1.63

18.8 ± 8.0

0.89 ± 0.81

-

449 ± 243

Pasvol 1991 (N = 43)

Low

IM

n = 20

20 mg/kg

10 mg/kg bd

N/A

15.3 ± 7.6

2.4 ± 1.7

15.7 ± 8.2

1.12 ± 0.56

1.22 ± 0.32

332 ± 254

Winstanley 1993 (N = 22)

Very

Low

IM

n = 10

20 mg/kg

10 mg/kg bd

N/A

15.7 ± 3.1

1.6 ± 1.7

-

-

-

-

van Hensbroek 1996 (N = 16)

Very

Low

IM

n = 10

20 mg/kg

10 mg/kg bd

N/A

16.36 ± 3.67

1.08 ± 0.37

15.31 ± 7.16

0.59 ± 0.25

1.32 ± 0.49

358 ± 164

Krishna 2001 (N = 120)

Very

Low

IM

n = 120

20 mg/kg

10 mg/kg bd

N/A

-

-

19.9 ± 4.4

0.05

-

-