Table 7 Characteristics of studies that evaluated risk of hypoglyacemia with IV-infused quinine (Systematic review 4)

Molyneux 1989

(N = 29)

Very low

2 to 9 years

Malawi

10 mg/kg in 5% glucose in half strength Darrow's solution

1 h

80

< 2.2

10 mg/kg in 5% glucose in half strength Darrow's solution

3 h

80

< 2.2

20 mg/kg in 5% glucose in half strength Darrow's solution

3 h

80

< 2.2

Okitolonda 1987

(N = 9)*

Very low

6 to 10 years

Zaïre

10 mg/kg in 30 ml saline supplemented with 2.5% glucose every 8 hours

1 h

105

< 2.8

Kawo 1991

(N = 97)

Very low

Up to 7 years

Tanzania

10 mg/kg in 10 ml/kg of 5% glucose every 8 hours

4 h

Not reported

< 2.2

Ogetii 2010

(N = 1237)

Low

Up to 12 years

Kenya

15 mg/kg loading dose in 5% dextrose then 10 mg/kg in 5% dextrose every 12 hours

2 h

Not reported

< 3, < 2.8 and < 2.2

20 mg/kg loading dose in 5% dextrose then 10 mg/kg in 5% dextrose every 8 hours

4 h

Not reported

< 3, < 2.8 and < 2.2

Taylor 1988

(N = 95)

Very low

7 months to 8 years

Malawi

20 mg/kg loading dose then 10 mg/kg every 8 hours

Loading dose 4 h,

then maintenance dose 2 to 8 h

80

< 2.2

Dondorp 2010

High

Up to 15 years

Multi-centre trial in Mozambique, The Gambia, Ghana, Kenya, Tanzania, Nigeria, Uganda, Rwanda and Democratic Republic of Congo

^¥20 mg/kg loading dose in 5-10 ml/kg of 5% dextrose then 10 mg/kg in 5-10 ml/kg of 5% dextrose every 8 hours

Loading dose 4 h,

then maintenance dose 2 to 8 h

Not reported

Not reported