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Table 7 Characteristics of studies that evaluated risk of hypoglyacemia with IV-infused quinine (Systematic review 4)

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

Study ID Evidence quality Age range Country IV Quinine Dose and diluent Infusion time Infusion rate (ml/kg/24 h) Glucose Threshold (mmol/l)
Molyneux 1989
(N = 29)
Very low 2 to 9 years Malawi 10 mg/kg in 5% glucose in half strength Darrow's solution 1 h 80 < 2.2
     10 mg/kg in 5% glucose in half strength Darrow's solution 3 h 80 < 2.2
     20 mg/kg in 5% glucose in half strength Darrow's solution 3 h 80 < 2.2
Okitolonda 1987
(N = 9)*
Very low 6 to 10 years Zaïre 10 mg/kg in 30 ml saline supplemented with 2.5% glucose every 8 hours 1 h 105 < 2.8
Kawo 1991
(N = 97)
Very low Up to 7 years Tanzania 10 mg/kg in 10 ml/kg of 5% glucose every 8 hours 4 h Not reported < 2.2
Ogetii 2010
(N = 1237)
Low Up to 12 years Kenya 15 mg/kg loading dose in 5% dextrose then 10 mg/kg in 5% dextrose every 12 hours 2 h Not reported < 3, < 2.8 and < 2.2
     20 mg/kg loading dose in 5% dextrose then 10 mg/kg in 5% dextrose every 8 hours 4 h Not reported < 3, < 2.8 and < 2.2
Taylor 1988
(N = 95)
Very low 7 months to 8 years Malawi 20 mg/kg loading dose then 10 mg/kg every 8 hours Loading dose 4 h,
then maintenance dose 2 to 8 h
80 < 2.2
Dondorp 2010 High Up to 15 years Multi-centre trial in Mozambique, The Gambia, Ghana, Kenya, Tanzania, Nigeria, Uganda, Rwanda and Democratic Republic of Congo ¥20 mg/kg loading dose in 5-10 ml/kg of 5% dextrose then 10 mg/kg in 5-10 ml/kg of 5% dextrose every 8 hours Loading dose 4 h,
then maintenance dose 2 to 8 h
Not reported Not reported
  1. *Data from N = 5 adults were excluded from this analysis
  2. Ogetti 2010 = Retrospective review of case notes. ¥Quinine was administered by the IM and IV route.