Table 3 Anti-relapse efficacy of a total tafenoquine dose 1.8 mg/kg (0.6 mg/kg/day for three days or 1.8 mg/kg once) monotherapy or in combination with chloroquine and other blood stage regimens.

TQ given alone after quinine pretreatment

6/6 (100)

CQ given sequentially after blood stage failure of first tafenoquine treatment regimen

2/2 (100)

CQ + TQ given simultaneously for first treatment

2/2 (100)

CQ given sequentially after blood stage failure of first relapse treatment

2/2 (100)

Treatment of second relapse

1/2 (50)

CQ + TQ given simultaneously for first treatment

5/5 (100)

TQ given with CQ after quinine pretreatment to eliminate blood stage parasites

6/6 (100)

TQ given as a single dose for first treatment (data not shown)

2/2 (100)

Simultaneous combination with artemether-lumefantrine for initial treatment

5/6 (83)

Simultaneous combination with atovaquone-proguanil for initial treatment (data not shown)

2/2 (100)

6/6 (100)

20/21 (95)

27/29 (93)

33/35 (94)