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Table 4 Case definition of clinical malaria

From: Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa

Criterion

Primary definition

Secondary definition 1

Secondary definition 2

Secondary definition 3

Threshold of P. falciparum asexual parasitaemia

>5,000 parasites/μL

>0 parasites/μL

>500 parasites/μL

>20,000 parasites/μL

Fever

axillary temperature ≥37.5°C

axillary temperature ≥37.5°Cor history of fever within 24 h of presentation

axillary temperature ≥37.5°C

axillary temperature ≥37.5°C)

Case detection

Child is unwell and brought to healthcare facility

Child is unwell and brought to healthcare facility

Child is unwell and brought to healthcare facility

Child is unwell and brought to healthcare facility

Other

OR

Meets primary case definition of severe malaria1

   
  1. 1 Refer to [22] for primary definition of severe malaria