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Table 5 Malaria recrudescence and reinfection rates at Day 28 by G6PD genotype and phenotype

From: Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

G6PD status

N

Recrudescence

n (%)

Reinfection

n (%)

Genotype*

   

   Deficient

184

11 (6.0)

49 (26.6)

   Heterozygous

273

11 (4.0)

71 (26.0)

   Normal

1588

82 (4.0)

488 (30.7)

   Total

2045

104 (5.1)

608 (29.7)

Phenotype**

   

   Deficient

146

9 (6.2)

39 (26.7)

   Intermediate

137

3 (2.2)

39 (28.5)

   Normal

1096

62 (5.7)

391 (35.7)

   Total

1379

74 (5.4)

469 (34.0)

  1. *G6PD genotype: male hemizygous = A-; male normal = A or B; female homozygous = A-/A-; female heterozygous = A/A- or B/A-; and female normal = A/A, B/B or B/A
  2. **Analysis performed for patients with G6PD phenotype with or without genotype available.
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Malaria Journal

ISSN: 1475-2875

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