Skip to main content

Table 6 Genotype association analysis

From: Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

SNP

(genotype model)

Genotype-based tests*

Adjusted analysis**

Multiple SNP analysis***

Chi-squared

p-value

OR

[95%, CI]

p-value

OR

[95%, CI]

p-value

rs1012356

(TT vs AT/AA)

17.20

0.001

1.15

[0.90 - 1.46]

0.27

1.23

[0.95 - 1.85]

0.09

rs2227491

(TT vs CT/CC)

6.90

0.07

1.04

[0.80 - 1.34]

0.78

0.97

[0.68 - 1.39]

0.88

rs2227485

(AA vs GG/AG)

11.30

0.01

1.04

[0.82 - 1.32]

0.74

0.89

[0.64 - 1.25]

0.50

rs2227478

(GG vs AA/AG)

6.60

0.09

1.14

[0.86 - 1.51]

0.36

1.21

[0.82 - 1.80]

0.34

rs2706384

(AA vs CC/AC)

21.80

0.0001

0.76

[0.64 - 0.92]

0.005

0.76

[0.71 - 0.92]

0.005

rs2057291

(AA vs GG/AG)

11.90

0.02

1.27

[1.02 - 1.57]

0.03

0.91

[0.71 - 1.17]

0.47

CD36 G1439C

(CC vs GG/CG)

9.30

0.03

-

-

-

-

ICAM1 CODON241

(AA vs GG/AG)

30.03

0.0001

0.98

[0.71 - 1.36]

0.92

1.04

[0.74 - 1.44]

0.84

rs20541

(TT vs CC/CT)

23.90

0.0001

0.89

[0.67 - 1.19]

0.44

1.07

[0.75 - 1.54]

0.70

TNF -376

(AA vs GG/AG)

13.40

0.004

1.17

[0.69 - 1.98]

0.56

0.95

[0.50 - 1.80]

0.87

rs3024500

(GG vs AA/AG)

8.80

0.03

1.04

[0.77 - 1.41]

0.79

1.10

[0.78 - 1.58]

0.60

RS1805015

(CC vs TT/CT)

8.70

0.03

0.84

[0.65 - 1.10]

0.21

0.66

[0.45 - 0.97]

0.03

rs17047660

(GG vs AA/AG)

7.20

0.07

0.95

[0.72 - 1.23]

0.68

1.32

[0.84 - 2.07]

0.23

rs17047661

(AA vs GG/AG)

7.40

0.06

0.88

[0.66 - 1.16]

0.36

0.72

[0.49 - 1.05]

0.09

rs17140229

(CC vs TT/CT)

8.60

0.04

1.08

[0.79 - 1.46]

0.62

1.41

[0.94 - 2.10]

0.09

rs1126535

(CC vs TT/CT)

21.60

0.0001

0.91

[0.67 - 1.22]

0.52

0.85

[0.51 - 1.40]

0.51

rs2230739

(GG vs AA/AG)

10.40

0.02

1.06

[0.80 - 1.39]

0.69

1.26

[0.82 - 1.92]

0.29

rs229587

(CC vs TT/CT)

8.50

0.04

0.97

[0.76 - 1.22]

0.76

1.02

[0.73 - 1.43]

0.92

rs2814778

(AA vs GG/AG)

33.03

0.0001

0.82

[0.53 - 1.28]

0.38

0.85

[0.53 - 1.36]

0.50

rs3092945

(CC vs TT/CT)

10.60

0.01

0.83

[0.61 - 1.11]

0.21

0.89

[0.60 - 1.34]

0.60

rs1128127

(AA vs GG/AG)

12.04

0.007

0.77

[0.59 - 0.99]

0.05

0.67

[0.45 - 0.99]

0.05

rs1803632

(GG vs CC/CG)

7.04

0.071

0.78

[0.58 - 1.05]

0.10

0.76

[0.49 - 1.17]

0.21

rs7935564

(AA vs GG/AG)

21.10

0.0001

1.02

[0.84 - 1.25]

0.81

0.93

[0.70 - 1.22]

0.59

rs4833095

(TT vs CC/CT)

6.90

0.08

0.75

[0.52 - 1.07]

0.12

0.86

[0.57 - 1.33]

0.50

rs5743809

(CC vs TT/CT)

11.40

0.01

1.25

[0.57 - 2.74]

0.59

1.23

[0.53 - 2.84]

0.63

  1. Highly significant associations (P < 0.01) are highlighted in bold; significant associations (0.01 < P < 0.05) are underlined. OR = odds ratio; *Single locus based tests; **Each SNP adjusted for age, ethnic group, gender, and study location. ***Multiple SNPs adjusted for ethnic group, age, gender, and study location.
Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us