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Table 6 Genotype association analysis

From: Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

SNP
(genotype model)
Genotype-based tests* Adjusted analysis** Multiple SNP analysis***
Chi-squared p-value OR
[95%, CI]
p-value OR
[95%, CI]
p-value
rs1012356
(TT vs AT/AA)
17.20 0.001 1.15
[0.90 - 1.46]
0.27 1.23
[0.95 - 1.85]
0.09
rs2227491
(TT vs CT/CC)
6.90 0.07 1.04
[0.80 - 1.34]
0.78 0.97
[0.68 - 1.39]
0.88
rs2227485
(AA vs GG/AG)
11.30 0.01 1.04
[0.82 - 1.32]
0.74 0.89
[0.64 - 1.25]
0.50
rs2227478
(GG vs AA/AG)
6.60 0.09 1.14
[0.86 - 1.51]
0.36 1.21
[0.82 - 1.80]
0.34
rs2706384
(AA vs CC/AC)
21.80 0.0001 0.76
[0.64 - 0.92]
0.005 0.76
[0.71 - 0.92]
0.005
rs2057291
(AA vs GG/AG)
11.90 0.02 1.27
[1.02 - 1.57]
0.03 0.91
[0.71 - 1.17]
0.47
CD36 G1439C
(CC vs GG/CG)
9.30 0.03 - - - -
ICAM1 CODON241
(AA vs GG/AG)
30.03 0.0001 0.98
[0.71 - 1.36]
0.92 1.04
[0.74 - 1.44]
0.84
rs20541
(TT vs CC/CT)
23.90 0.0001 0.89
[0.67 - 1.19]
0.44 1.07
[0.75 - 1.54]
0.70
TNF -376
(AA vs GG/AG)
13.40 0.004 1.17
[0.69 - 1.98]
0.56 0.95
[0.50 - 1.80]
0.87
rs3024500
(GG vs AA/AG)
8.80 0.03 1.04
[0.77 - 1.41]
0.79 1.10
[0.78 - 1.58]
0.60
RS1805015
(CC vs TT/CT)
8.70 0.03 0.84
[0.65 - 1.10]
0.21 0.66
[0.45 - 0.97]
0.03
rs17047660
(GG vs AA/AG)
7.20 0.07 0.95
[0.72 - 1.23]
0.68 1.32
[0.84 - 2.07]
0.23
rs17047661
(AA vs GG/AG)
7.40 0.06 0.88
[0.66 - 1.16]
0.36 0.72
[0.49 - 1.05]
0.09
rs17140229
(CC vs TT/CT)
8.60 0.04 1.08
[0.79 - 1.46]
0.62 1.41
[0.94 - 2.10]
0.09
rs1126535
(CC vs TT/CT)
21.60 0.0001 0.91
[0.67 - 1.22]
0.52 0.85
[0.51 - 1.40]
0.51
rs2230739
(GG vs AA/AG)
10.40 0.02 1.06
[0.80 - 1.39]
0.69 1.26
[0.82 - 1.92]
0.29
rs229587
(CC vs TT/CT)
8.50 0.04 0.97
[0.76 - 1.22]
0.76 1.02
[0.73 - 1.43]
0.92
rs2814778
(AA vs GG/AG)
33.03 0.0001 0.82
[0.53 - 1.28]
0.38 0.85
[0.53 - 1.36]
0.50
rs3092945
(CC vs TT/CT)
10.60 0.01 0.83
[0.61 - 1.11]
0.21 0.89
[0.60 - 1.34]
0.60
rs1128127
(AA vs GG/AG)
12.04 0.007 0.77
[0.59 - 0.99]
0.05 0.67
[0.45 - 0.99]
0.05
rs1803632
(GG vs CC/CG)
7.04 0.071 0.78
[0.58 - 1.05]
0.10 0.76
[0.49 - 1.17]
0.21
rs7935564
(AA vs GG/AG)
21.10 0.0001 1.02
[0.84 - 1.25]
0.81 0.93
[0.70 - 1.22]
0.59
rs4833095
(TT vs CC/CT)
6.90 0.08 0.75
[0.52 - 1.07]
0.12 0.86
[0.57 - 1.33]
0.50
rs5743809
(CC vs TT/CT)
11.40 0.01 1.25
[0.57 - 2.74]
0.59 1.23
[0.53 - 2.84]
0.63
  1. Highly significant associations (P < 0.01) are highlighted in bold; significant associations (0.01 < P < 0.05) are underlined. OR = odds ratio; *Single locus based tests; **Each SNP adjusted for age, ethnic group, gender, and study location. ***Multiple SNPs adjusted for ethnic group, age, gender, and study location.