Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (min) | Clearance (L/kg/hr) | Volume (L/kg) | Half-life (min) | AUC (ng*hr/mL) |
---|---|---|---|---|---|---|---|
[10] Ilett et al, 2002 | 11 Vietnamese adults with uncomplicated falciparum malaria 120 mg AS administered by intramuscular injection | 884†a | 12a | 2.9 | 2.6 | 41 | 999†|
[21] Hien et al, 2004 | 9 Vietnamese adults with severe falciparum malaria 2.4 mg/kg AS administered by intramuscular injection | 2195†a |  | 2.84a | 1.09a | 30a | 856†a |
[12] Nealon et al, 2002 | 28 paediatric Gabonese patients with severe malaria randomized into two groups Group 1: 2.4 mg/kg IV AS, followed by 1.2 mg/kg IM AS 12 hours later Group 2: 2.4 mg/kg IM AS, followed by 1.2 mg/kg IV AS 12 hours later | Group 1: 615†a Group 2: 661†a | Group 1: 7.2a Group 2: 8.0a | Group 1: 2.4†a Group 2: 3.48†a | Group 1 Vss/F: 2.07a Group 2 Vss/F: 3.98a | Group 1: 25.2a Group 2: 48.2a | Group 1: 535†a Group 2: 544†a |