Skip to main content

Table 3 Summary of AS pharmacokinetic results following IM AS administration.

From: Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

Ref.

Subjects & Regimen

Cmax (ng/mL)

Tmax (min)

Clearance (L/kg/hr)

Volume (L/kg)

Half-life (min)

AUC (ng*hr/mL)

[10]

Ilett et al, 2002

11 Vietnamese adults with uncomplicated falciparum malaria

120 mg AS administered by intramuscular injection

884†a

12a

2.9

2.6

41

999†

[21]

Hien et al, 2004

9 Vietnamese adults with severe falciparum malaria

2.4 mg/kg AS administered by intramuscular injection

2195†a

 

2.84a

1.09a

30a

856†a

[12]

Nealon et al, 2002

28 paediatric Gabonese patients with severe malaria randomized into two groups

Group 1: 2.4 mg/kg IV AS, followed by 1.2 mg/kg IM AS 12 hours later

Group 2: 2.4 mg/kg IM AS, followed by 1.2 mg/kg IV AS 12 hours later

Group 1:

615†a

Group 2:

661†a

Group 1:

7.2a

Group 2:

8.0a

Group 1:

2.4†a

Group 2:

3.48†a

Group 1 Vss/F: 2.07a

Group 2 Vss/F: 3.98a

Group 1:

25.2a

Group 2:

48.2a

Group 1:

535†a

Group 2:

544†a

  1. Values given as mean unless otherwise specified.
  2. †Units converted to uniform scale a. Median