Table 4 Summary of DHA pharmacokinetic results following IM AS administration.

[10]

Ilett et al, 2002

11 Vietnamese adults with uncomplicated falciparum malaria

120 mg AS administered by intramuscular injection

1166†^a

45^a

0.73

1.1

64

2474†

F: 88%

[21]

Hien et al, 2004

9 Vietnamese adults with severe falciparum malaria

2.4 mg/kg AS administered by intramuscular injection

870†^a

35^a

1.18^a

1.79^a

52.7^a

1496†^a

[12]

Nealon et al, 2002

28 paediatric Gabonese patients with severe malaria randomized into two groups

Group 1: 2.4 mg/kg IV AS, followed by 1.2 mg/kg IM AS 12 hours later

Group 2: 2.4 mg/kg IM AS, followed by 1.2 mg/kg IV AS 12 hours later

Group 1:

341^a

Group 2:

626^a

Group 1:

25.9^a

Group 2:

40.5^a

Group 1:

2.16†^a

Group 2:

1.5†^a

Group 1:

Vc/F: 1.2^a

Vss/F: 1.32^a

Group 2:

Vc/F: 1.2^a

Vss/F: 1.28^a

Group 1:

31.9^a

Group 2:

40.2^a

Group 1:

396†^a

Group 2:

1123†^a

Combined group F: 86.37%^a